SPAM1 / PH20

Sperm Adhesion Molecule 1 (PH-20 HYALURONIDASE, ZONA PELLUCIDA BINDING)

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

SPAM1 / PH20 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SPAM1 / PH20 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129937

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.3 kDa

Price:

100 µg/$494

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Human SPAM1 / PH20 Protein (Recombinant GST, N-terminus) (aa346-445) - LS-G60188

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SPAM1 / PH20 Protein (Recombinant GST) (Full Length) - LS-G30509

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.2 kDa

Price:

2 µg/$439

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Human SPAM1 / PH20 Protein (Recombinant His-SUMO) (aa36-490) - LS-G21212

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

67.83 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SPAM1 / PH20 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65955

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.2 kDa

Price:

20 µg/$1,107

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SPAM1 / PH20 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99971

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.2 kDa

Price:

100 µg/$494

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