SPAM1 / PH20

Sperm Adhesion Molecule 1 (PH-20 HYALURONIDASE, ZONA PELLUCIDA BINDING)

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

Antibodies (18)

Proteins (6)

ELISA Kits (2)

Type

Over-Expression Lysate (2)

Primary (18)

Recombinant (4)

Sandwich (2)

Target

SPAM1 / PH20 (26)

Reactivity

Human (19)

Mouse (6)

Rat (5)

Chimpanzee (3)

Gibbon (3)

Orangutan (3)

Application

IHC (2)

WB (14)

ELISA (5)

ICC (1)

IF (2)

Peptide-ELISA (1)

Host

rabbit (18)

Isotype

IgG (8)

Clonality

polyclonal pc (18)

Format

96-Well Microplate (2)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

Unconjugated (9)

Epitope

Internal (4)

aa36-490 (4)

aa437-486 (4)

aa216-244 (1)

Publications

No (25)

Yes (1)

Sample Type

Cell Lysates (2)

Tissue Homogenates (2)

Tag

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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SPAM1 / PH20 Antibody (aa36-490) LS-C370363

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa36-490) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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SPAM1 / PH20 Antibody (aa36-490, HRP) LS-C370365

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa36-490) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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SPAM1 / PH20 Antibody (aa36-490, Biotin) LS-C370366

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa36-490) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$361

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SPAM1 / PH20 Antibody (aa36-490, FITC) LS-C370367

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa36-490) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPAM1 / PH20 Antibody LS-C331909

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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SPAM1 / PH20 Antibody LS-C482352

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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SPAM1 / PH20 Antibody LS-C752532

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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Human SPAM1 / PH20 (Sandwich ELISA) ELISA Kit - LS-F74584

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$595

Select

SPAM1 / PH20 Antibody LS-C192906

(4.0) Rating

(1) Publication(s)

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

SPAM1 / PH20 Antibody (aa437-486) LS-C151669

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa437-486) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SPAM1 / PH20 Antibody (aa437-486, HRP) LS-C471884

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa437-486) (HRP) Antibody

Reactivity:

Human, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SPAM1 / PH20 Antibody (aa437-486, Biotin) LS-C471882

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa437-486) (Biotin) Antibody

Reactivity:

Human, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SPAM1 / PH20 Antibody (aa437-486, FITC) LS-C471883

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa437-486) (FITC) Antibody

Reactivity:

Human, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPAM1 / PH20 Antibody (Internal) LS-C345607

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SPAM1 / PH20 Antibody (Internal, HRP) LS-C471887

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (Internal) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SPAM1 / PH20 Antibody (Internal, Biotin) LS-C471885

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SPAM1 / PH20 Antibody (Internal, FITC) LS-C471886

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SPAM1 / PH20 Antibody (aa216-244) LS-C806362

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal (aa216-244) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

Human SPAM1 / PH20 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129937

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.3 kDa

Price:

100 µg/$494

Select

SPAM1 / PH20 Antibody LS-C770832

Antibody:

SPAM1 / PH20 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

Human SPAM1 / PH20 Protein (Recombinant GST, N-terminus) (aa346-445) - LS-G60188

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SPAM1 / PH20 Protein (Recombinant GST) (Full Length) - LS-G30509

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.2 kDa

Price:

2 µg/$439

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Human SPAM1 / PH20 Protein (Recombinant His-SUMO) (aa36-490) - LS-G21212

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

67.83 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SPAM1 / PH20 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65955

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.2 kDa

Price:

20 µg/$1,107

Select

Mouse SPAM1 / PH20 (Sandwich ELISA) ELISA Kit - LS-F74358

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$612

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