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SOX7
SRY (sex determining region Y)-box 7
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.
| Gene Name: | SRY (sex determining region Y)-box 7 |
| Family/Subfamily: | Transcription factor |
| Synonyms: | SOX7, Transcription factor SOX-7, SOX7 transcription factor |
| Target Sequences: | NM_031439 NP_113627.1 Q9BT81 |
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