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SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).
Gene Name: | SRY (sex determining region Y)-box 21 |
Family/Subfamily: | Transcription factor |
Synonyms: | SOX21, SOXA, Transcription factor SOX-21, SRY-box 21, SOX-A, SOX25 |
Target Sequences: | NM_007084 NP_009015.1 Q9Y651 |
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