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SOX2

SRY (sex determining region Y)-box 2

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.

Gene Name: SRY (sex determining region Y)-box 2
Family/Subfamily: Transcription factor
Synonyms: SOX2, MCOPS3, Transcription factor SOX2, ANOP3, Transcription factor SOX-2, SRY-related HMG-box gene 2
Target Sequences: L07335 AAA35997.1 P48431

Publications (8)

1
Developmental changes in the expression of sox2 in the zebrafish brain. Carlisle FA, Steel KP, Lewis MA. Microscopy research and technique. 2010 (WB; Zebrafish) [PubMed:20734413] Related Antibodies: LS-C31802.
2
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X. Development (Cambridge, England). 2011 138:971-81. (ICC, IHC; Mouse) [PubMed:21303850]
3
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A. Molecular and cellular biology. 2011 31:4593-608. [PubMed:21930787] [PMC:PMC3209254]
4
Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin. Yu SC, Xiao HL, Jiang XF, Wang QL, Li Y, Yang XJ, Ping YF, Duan JJ, Jiang JY, Ye XZ, Xu SL, Xin YH, Yao XH, Chen JH, Chu WH, Sun W, Wang B, Wang JM, Zhang X, Bian XW. Stem cells (Dayton, Ohio). 2012 30:108-20. [PubMed:22131169]
5
Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine) [Full Text Article] [PubMed:26537238] [PMC:PMC4841859] Related Antibodies: LS-B4562.
6
MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells. Lili Ren, Boya Deng, Vassiliki Saloura, Jae-Hyun Park, Yusuke Nakamura. Oncology reports. 2019 Apr;41:2540-2548. [Full Text Article] [PubMed:30720113]
7
Tumour angiogenesis normalized by myo-inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response. Bouchra El Hafny-Rahbi, Klaudia Brodaczewska, Guillaume Collet, Aleksandra Majewska , Krzysztof Klimkiewicz , Anthony Delalande, Catherine Grillon, Claudine Kieda. Journal of cellular and molecular medicine. 2021 Apr;;25:3284-3299. [Full Text Article] [PubMed:33624446] [PMC:PMC8034441] Related Antibodies: LS-C108535.
8
Sox-2 in taste bud and lateral line system of zebrafish during development. German[Character e0] A, Montalbano G, Guerrera MC, Laura R, Levanti M, Abbate F, de Carlos F, Vega JA, Ciriaco E. Neuroscience letters. 2009 Dec;467:36-9. [Full Text Article] [PubMed:19800392] Related Antibodies: LS-C31802.
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Proteins (12)
Over-Expression Lysate (3)
Recombinant (9)
SOX2 (12)
No (11)
Yes (1)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (1)
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Human (11)
293T Cells (1)
E. coli (7)
HEK 293 Cells (2)
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SOX2 Protein
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E. coli
6His, N-terminus
36.4 kDa
50 µg/$315; 100 µg/$365; 500 µg/$949
SOX2 Protein
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E. coli
His-SUMO
50.3 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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E. coli
None
Less than 0.1 ng/µg of protein (less than 1EU/µg).
34.3 kDa
5 µg/$268; 25 µg/$349
SOX2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SOX2 Protein - Purified recombinant protein SOX2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$1,107
SOX2 Protein - Recombinant Sex Determining Region Y Box Protein 2 By SDS-PAGE
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E. coli
His-T7
26.4 kDa
10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304
SOX2 Protein - 12.5% SDS-PAGE of human SOX2 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.61 kDa
2 µg/$439
SOX2 Protein
Select
E. coli
6His, N-terminus
36 kDa
100 µg/$298
SOX2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.1 kDa
100 µg/$494
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E. coli
Tat
Less than 0.1 ng/µg of protein (less than 1EU/µg).
36 kDa
5 µg/$268; 25 µg/$349
SOX2 Protein
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E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
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293T Cells
Myc-DDK (Flag)
34.1 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).