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SOX12
SRY (sex determining region Y)-box 12
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.
| Gene Name: | SRY (sex determining region Y)-box 12 |
| Family/Subfamily: | Transcription factor |
| Synonyms: | SOX12, Protein SOX-22, SOX-22 protein, SOX22, SRY-related HMG-box gene 22, Sox-12, Transcription factor SOX-12 |
| Target Sequences: | NM_006943 NP_008874.2 O15370 |
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