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SORCS2

sortilin-related VPS10 domain containing receptor 2

SORCS2 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system.

Gene Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: SORCS2, KIAA1329, VPS10 domain receptor protein
Target Sequences: AB037750 BAA92567.1 Q96PQ0

Publications (2)

1
SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Malik AR, Szydlowska K, Nizinska K, Asaro A, van Vliet EA, Popp O, Dittmar G, Fritsche-Guenther R, Kirwan JA, Nykjaer A, Lukasiuk K, Aronica E, Willnow TE. Cell reports. 2019 March;26:2792-2804. [Full Text Article] [PubMed:30840898] [PMC:PMC6410498] Related Antibodies: LS-C501334.
2
SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis. Anna R Malik, Janet Lips, Malgorzata Gorniak-Walas, Diede W M Broekaart, Antonino Asaro, Melanie T C Kuffner, Christian J Hoffmann, Majed Kikhia, Monika Dopatka, Philipp Boehm-Sturm, Susanne Mueller, Ulrich Dirnagl, Eleonora Aronica, Christoph Harms, Thomas E Willnow. Glia. 2020 June;68:1304-1316. [Full Text Article] [PubMed:31898841] Related Antibodies: LS-C501334.

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Proteins (3)
Over-Expression Lysate (2)
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SORCS2 (3)
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GST, N-terminus (1)
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293T Cells (1)
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Wheat Germ Extract (1)
SORCS2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SORCS2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
128 kDa
20 µg/$215
SORCS2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
128 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).