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SOD1 / Cu-Zn SOD

superoxide dismutase 1, soluble

SOD1 / Cu-Zn SOD binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

Gene Name: superoxide dismutase 1, soluble
Synonyms: SOD1, ALS, ALS1, Cu/Zn superoxide dismutase, HSod1, Homodimer, IPOA, SOD, soluble, SOD, Superoxide dismutase [Cu-Zn], Superoxide dismutase 1, Indophenoloxidase A, Superoxide dismutase, cystolic
Target Sequences: NM_000454 NP_000445.1 P00441

Publications (6)

1
Effect of specific activation of ?-aminobutyric acid receptor in vivo on oxidative stress-induced damage after extended hepatectomy. Gardner LB, Hori T, Chen F, Baine AM, Hata T, Uemoto S, Nguyen JH. Hepatology research : the official journal of the Japan Society of Hepatology. 2012 42:1131-40. (WB; Mouse) [Full Text Article] [PubMed:22583816] [PMC:PMC3438378]
2
Pretreatment of liver grafts in vivo by ?-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat. Hori T, Gardner LB, Hata T, Chen F, Baine AM, Uemoto S, Nguyen JH. Annals of transplantation : quarterly of the Polish Transplantation Society. 2013 18:299-313. (WB; Rat) [Full Text Article] [PubMed:23792534] [PMC:PMC3912510]
3
Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats. Hori T, Uemoto S, Chen F, Gardner LB, Baine AM, Hata T, Kogure T, Nguyen JH. World journal of hepatology. 2014 6:72-84. (WB; Rat) [PubMed:24575166] [PMC:PMC3934637]
4
Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice. Wang X, Gu H, Huang W, Peng J, Li Y, Yang L, Qin D, Essandoh K, Wang Y, Peng T, Fan GC. Diabetes. 2016 October;65:3111-28. [Full Text Article] [PubMed:27284111] [PMC:PMC5033265]
5
Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study. Domenico Corradi, Sergio Callegari, Roberta Maestri, David Ferrara, Domenica Mangieri, Rossella Alinovi, Paola Mozzoni, Silvana Pinelli, Matteo Goldoni, Ylenia Adelaide Privitera, Veronica Bartoli, Ettore Astorri, Emilio Macchi, Augusto Vaglio, Stefano Benussi, Ottavio Alfieri. Journal of cardiovascular electrophysiology. 2012 March;23:271-9. [Full Text Article] [PubMed:21954878]
6
Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction. Inas A Harb, Hend Ashour, Abeer Mostafa, Hala M El Hanbuli, Eman Hassan Nadwa. Clinical and experimental pharmacology & physiology. 2022 March;49:406-418. [Full Text Article] [PubMed:34796981]
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Proteins (26)
Over-Expression Lysate (2)
Recombinant (22)
SOD1 / Cu-Zn SOD (26)
No (26)
10His-SUMO, N-terminus + Myc, C-terminus (1)
6His, N-terminus (2)
GST (1)
His (9)
His, N-Terminal (2)
His-T7 (4)
Myc-DDK (Flag) (3)
Bovine (1)
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Human (14)
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293T Cells (1)
E. coli (21)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (8)
Low endotoxin level (2)
Biologically active (3)
SOD1 / Cu-Zn SOD Protein - Recombinant Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His, N-Terminal
17.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
SOD1 / Cu-Zn SOD Protein
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Yeast
His
17.8 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
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E. coli
None
Biologically active
31.6 kDa
100 µg/$425; 500 µg/$789
Select
E. coli
His
Biologically active
39.9 kDa
100 µg/$468; 500 µg/$946
Select
E. coli
None
15.9 kDa
5 µg/$329; 25 µg/$412; 1000 µg/$3,417
Select
E. coli
None
31.6 kDa
20 µg/$329; 100 µg/$412; 1000 µg/$1,159
SOD1 / Cu-Zn SOD Protein
Select
E. coli
His, N-Terminal
15.8 kDa
50 µg/$419
SOD1 / Cu-Zn SOD Protein - Recombinant Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His
17 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
SOD1 / Cu-Zn SOD Protein - 12.5% SDS-PAGE of human SOD1 stained with Coomassie Blue
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Wheat Germ Extract
GST
42.68 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
His
19.9 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SOD1 / Cu-Zn SOD Protein - Recombinant  Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His-T7
19.1 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
SOD1 / Cu-Zn SOD Protein - Recombinant  Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His-T7
19.4 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
SOD1 / Cu-Zn SOD Protein - Recombinant  Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His-T7
19.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
SOD1 / Cu-Zn SOD Protein - Recombinant  Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His-T7
19.3 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
SOD1 / Cu-Zn SOD Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
SOD1 / Cu-Zn SOD Protein - Purified recombinant protein SOD1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
15.8 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
15.8 kDa
20 µg/$150
SOD1 / Cu-Zn SOD Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.8 kDa
100 µg/$494
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E. coli
His
16.8 kDa
100 µg/$502
Select
E. coli
153 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.94 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
SOD1 / Cu-Zn SOD Protein
Select
E. coli
None
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
SOD1 / Cu-Zn SOD Protein
Select
E. coli
6His, N-terminus
18 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.1kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
SOD1 / Cu-Zn SOD Protein - Recombinant Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His
17.1 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
SOD1 / Cu-Zn SOD Protein - Recombinant Superoxide Dismutase 1, Soluble By SDS-PAGE
Select
E. coli
His
16.9 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).