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SOCS6 / SOCS-6
suppressor of cytokine signaling 6
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
| Gene Name: | suppressor of cytokine signaling 6 |
| Synonyms: | SOCS6, CIS4, Cish4, SOCS-4, SSI4, STAT induced STAT inhibitor-4, SOCS-6, CIS-4, HSPC060, STAI4, STATI4 |
| Target Sequences: | NM_004232 NP_004223.2 O14544 |
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