SOCS3

suppressor of cytokine signaling 3

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

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Products

ELISA Kits (25)

Type

Custom (3)

Sandwich (19)

Sandwich CLIA (3)

Target

SOCS3 (25)

Reactivity

Human (6)

Mouse (5)

Rat (6)

Chicken (2)

Dog (1)

Guinea pig (1)

Monkey (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (3)

96-Well Strip Plate (20)

Publications

No (25)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (5)

Plasma (14)

Serum (14)

Tissue Homogenates (8)

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Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F18300

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse SOCS3 (Sandwich ELISA) ELISA Kit - LS-F8568

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$818

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Rat SOCS3 (Sandwich ELISA) ELISA Kit - LS-F12629

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Human SOCS3 (CLIA) ELISA Kit - LS-F30220

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

7.813 - 500 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F22989

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F4903

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.63 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F34944

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat SOCS3 (Sandwich ELISA) ELISA Kit - LS-F34946

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rabbit SOCS3 (Sandwich ELISA) ELISA Kit - LS-F48245

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Chicken SOCS3 (Sandwich ELISA) ELISA Kit - LS-F48246

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Monkey SOCS3 (Sandwich ELISA) ELISA Kit - LS-F48244

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Sheep SOCS3 (Sandwich ELISA) ELISA Kit - LS-F48248

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

7.813 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

Select

Guinea pig SOCS3 (Sandwich ELISA) ELISA Kit - LS-F48247

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Bovine SOCS3 (Custom ELISA) ELISA Kit - LS-F18297

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse SOCS3 (Custom ELISA) ELISA Kit - LS-F18298

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Dog SOCS3 (Custom ELISA) ELISA Kit - LS-F18299

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

Select

Mouse SOCS3 (CLIA) ELISA Kit - LS-F30961

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat SOCS3 (Sandwich ELISA) ELISA Kit - LS-F21609

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Mouse SOCS3 (Sandwich ELISA) ELISA Kit - LS-F21452

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Mouse SOCS3 (Sandwich ELISA) ELISA Kit - LS-F35775

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat SOCS3 (CLIA) ELISA Kit - LS-F37736

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat SOCS3 (Sandwich ELISA) ELISA Kit - LS-F54876

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$992

Select

Human SOCS3 (Sandwich ELISA) ELISA Kit - LS-F55594

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$929

Select

Rat SOCS3 (Sandwich ELISA) ELISA Kit - LS-F8511

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$856

Select

Chicken SOCS3 (Sandwich ELISA) ELISA Kit - LS-F12630

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$929

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