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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SOCS3

suppressor of cytokine signaling 3

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

Gene Name: suppressor of cytokine signaling 3
Synonyms: SOCS3, Cish3, Cytokine-induced SH2 protein 3, CIS-3, CIS3, SSI-3, STAT-induced STAT inhibitor 3, SSI3, ATOD4, SOCS-3
Target Sequences: NM_003955 NP_003946.3 O14543

Publications (3)

1
Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. Persico M, Capasso M, Russo R, Persico E, Croc L, Tiribelli C, Iolascon A. Gut. 2008 57:507-15. [PubMed:17881539]
2
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:14948-53. [PubMed:19706421] [PMC:PMC2736463]
3
Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways. Nguyen KD, Macaubas C, Nadeau KC, Truong P, Yoon T, Lee T, Park JL, Mellins ED. Blood. 2011 117:3793-8. [PubMed:21325601] [PMC:PMC3296631]

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SOCS3 (80)
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IHC (39)
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rabbit (54)
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Epitope
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aa213-225 (1)
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aa71-85 (1)
Publications
No (80)
Showing 1-25 of 80 results

SOCS3 Antibody (clone SO1) IHC-plus™ LS-B3317
Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3
Human
ELISA IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-SOCS3 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-SOCS3 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

SOCS3 Antibody (clone 11C5) LS-C172981
Mouse Monoclonal [clone 11C5] (IgG1) to Human SOCS3
Human
Flo IF WB
Unconjugated
100µl 0.99mg/ml  $335.00
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.

SOCS3 Antibody (clone 5D4) LS-C172776
Mouse Monoclonal [clone 5D4] (IgG2b) to Human SOCS3
Human
Flo IF IHC IHC-P WB
Unconjugated
100µl 0.8mg/ml  $335.00
IHC of paraffin-embedded Human liver tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Human liver tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-SOCS3 mouse monoclonal antibody.

SOCS3 Antibody (clone 8G3) LS-C173025
Mouse Monoclonal [clone 8G3] (IgG2a) to Human SOCS3
Human
Flo IF IHC IHC-P WB
Unconjugated
100µl  $335.00
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.

SOCS3 Antibody (Internal) LS-C353123
Rabbit Polyclonal to Human SOCS3
Chicken, Sheep, Bovine, Mouse, Dog, Rat, Pig, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of SOCS3 expression in MOLT4 (A); A431 (B); MCF7 (C); Raw264.7 (D); H9C2 (E) whole cell lysates.
Western blot analysis of SOCS3 expression in MOLT4 (A); A431 (B); MCF7 (C); Raw264.7 (D); H9C2 (E) whole cell lysates.

SOCS3 Antibody LS-C393168
Rabbit Polyclonal to Human SOCS3
Mouse, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
100µl  $305.00

SOCS3 Antibody (clone 3D3) LS-C173003
Mouse Monoclonal [clone 3D3] (IgG2a) to Human SOCS3
Human
Flo IF IHC IHC-P WB
Unconjugated
100µl 0.76mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-SOCS3 mouse monoclonal antibody.

SOCS3 Antibody (aa1-225) LS-C296550
Rabbit Polyclonal (IgG) to Mouse SOCS3
Mouse
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $515.00; 10ml 0.5mg/ml  $2,040.00
Western blot of recombinant SOCS3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant SOCS3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SOCS3 Antibody (aa1-225, Biotin) LS-C297684
Rabbit Polyclonal (IgG) to Mouse SOCS3
Mouse
IHC WB
Biotin Conjugated
100µl 0.5mg/ml  $425.00
Western blot of recombinant SOCS3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant SOCS3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SOCS3 Antibody (clone 7E10) LS-C173039
Mouse Monoclonal [clone 7E10] (IgG1) to Human SOCS3
Human
Flo IF IHC IHC-P WB
Unconjugated
100µl 0.46mg/ml  $335.00
IHC of paraffin-embedded Human Kidney tissue using anti-SOCS3 mouse monoclonal antibody.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
IHC of paraffin-embedded Human Kidney tissue using anti-SOCS3 mouse monoclonal antibody.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.

SOCS3 Antibody (aa213-225) LS-C55482
Goat Polyclonal to Human SOCS3
Rabbit, Mouse, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA WB
Unconjugated
100µg 0.5mg/ml  $405.00
Antibody staining (5 ug/ml) of MOLT-4 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Antibody staining (5 ug/ml) of MOLT-4 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

SOCS3 Antibody (C-Terminus) LS-C33939
Rabbit Polyclonal to Human SOCS3
Human
WB
Unconjugated
50µg 0.2mg/ml  $305.00

SOCS3 Antibody LS-C660599
Rabbit Polyclonal (IgG) to Human SOCS3
Human
ELISA IF IHC IP WB
Unconjugated
100µg  $435.00

SOCS3 Antibody (clone 3B8) LS-C173038
Mouse Monoclonal [clone 3B8] (IgG2b) to Human SOCS3
Human
Flo IF WB
Unconjugated
100µl 0.83mg/ml  $335.00
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.

SOCS3 Antibody (clone 6C2) LS-C173019
Mouse Monoclonal [clone 6C2] (IgG2a) to Human SOCS3
Human
Flo IF WB
Unconjugated
100µl 1mg/ml  $335.00
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.

SOCS3 Antibody (clone 15F9) LS-C173037
Mouse Monoclonal [clone 15F9] (IgG2b) to Human SOCS3
Human
IHC IHC-P WB
Unconjugated
100µl 0.81mg/ml  $335.00
IHC of paraffin-embedded Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SOCS3 mouse monoclonal antibody.

SOCS3 Antibody LS-C401038
Rabbit Polyclonal (IgG) to Human SOCS3
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human liver cancer using SOCS3 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human lung cancer using SOCS3 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human liver cancer using SOCS3 Polyclonal Antibody at dilution of 1:20.
Immunohistochemistry of Human lung cancer using SOCS3 Polyclonal Antibody at dilution of 1:20.

SOCS3 Antibody (clone 6F3) LS-C172777
Mouse Monoclonal [clone 6F3] (IgG1) to Human SOCS3
Human
Flo WB
Unconjugated
100µl 0.76mg/ml  $335.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-SOCS3 antibody, and then analyzed by flow cytometry.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-SOCS3 antibody, and then analyzed by flow cytometry.

SOCS3 Antibody (aa71-85) LS-C312859
Rabbit Polyclonal to Human SOCS3
Chicken, Sheep, Bovine, Rat, Pig, Horse, Bat, Mouse, Guinea pig, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
WB of SOCS3 antibody. Lane 1: JURKAT Cell Lysate. Lane 2: CEM Cell Lysate. Lane 3: RAJI Cell Lysate.
WB of SOCS3 antibody. Lane 1: JURKAT Cell Lysate. Lane 2: CEM Cell Lysate. Lane 3: RAJI Cell Lysate.

SOCS3 Antibody (clone 5C2) LS-C173028
Mouse Monoclonal [clone 5C2] (IgG2a) to Human SOCS3
Human
IF WB
Unconjugated
100µl 0.73mg/ml  $335.00
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.

SOCS3 Antibody LS-C359430
Rabbit Polyclonal to Human SOCS3
Cat, Human, Primate
IHC IHC-P WB
Unconjugated
100µg 0.5mg/ml  $335.00
Immunohistochemistry-Paraffin: SOCS3 Antibody - Human kidney probed with SOCS3 antibody at 5 ug/ml.
Western Blot: SOCS3 Antibody - analysis of SOCS3. Jurkat lysate in the 1) absence and 2) presence of immunizing peptide probed with 4 ug/ml of SOCS3 antibody. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: SOCS3 Antibody - Human kidney probed with SOCS3 antibody at 5 ug/ml.
Western Blot: SOCS3 Antibody - analysis of SOCS3. Jurkat lysate in the 1) absence and 2) presence of immunizing peptide probed with 4 ug/ml of SOCS3 antibody. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

SOCS3 Antibody (clone 6C12) LS-C173002
Mouse Monoclonal [clone 6C12] (IgG1) to Human SOCS3
Human
IF WB
Unconjugated
100µl 0.46mg/ml  $335.00
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
Anti-SOCS3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOCS3.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.

SOCS3 Antibody (Internal) LS-C209738
Rabbit Polyclonal (IgG) to Mouse SOCS3
Mouse, Human
ELISA WB
Unconjugated
50µg 0.2mg/ml  $335.00

SOCS3 Antibody LS-C193935
Rabbit Polyclonal (IgG) to Human SOCS3
Mouse, Human
IHC WB
Unconjugated
100µg 1ml  $860.00

SOCS3 Antibody LS-C192276
Rabbit Polyclonal to Human SOCS3
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00
Western blot of SOCS3 pAb in extracts from K562 cells.
Western blot of SOCS3 pAb in extracts from K562 cells.
Showing 1-25 of 80 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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