SNX27

sorting nexin family member 27

Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SNX27 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Purified (1)

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Human SNX27 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72315

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.6 kDa

Price:

20 µg/$1,107

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Human SNX27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91998

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.6 kDa

Price:

20 µg/$215

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Human SNX27 Protein (Recombinant GST) (Full Length) - LS-G35513

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.83 kDa

Price:

10 µg/$479; 25 µg/$670

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SNX27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101978

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.6 kDa

Price:

100 µg/$710

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