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SNX1
sorting nexin 1
May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
| Gene Name: | sorting nexin 1 |
| Synonyms: | SNX1, HsT17379, SNX1A, Sorting nexin 1, Sorting nexin 1A, Sorting nexin-1, VPS5 |
| Target Sequences: | NM_003099 NP_003090.2 Q13596 |
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