SNW1 / SKIP

SNW domain containing 1

Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SNW1 / SKIP (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human SNW1 / SKIP Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61883

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SNW1 / SKIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77757

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.3 kDa

Price:

20 µg/$215

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SNW1 / SKIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101063

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.3 kDa

Price:

100 µg/$710

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