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SNCB / Beta-Synuclein
synuclein, beta
SNCB / Beta-Synuclein is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
| Gene Name: | synuclein, beta |
| Synonyms: | SNCB, Beta Synuclein, Beta-synuclein, Synuclein, beta |
| Target Sequences: | NM_003085 NP_003076.1 Q16143 |
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