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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SNCA / Alpha-Synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1
Target Sequences: NM_000345 NP_000336.1 P37840

Publications (3)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852]

Filtered by: None
Target
SNCA / Alpha-Synuclein (158)
Reactivity
Human (133)
Mouse (71)
Rat (81)
Bovine (12)
Chicken (2)
Chimpanzee (3)
Cow (1)
Dog (12)
Gibbon (3)
Guinea pig (4)
Hamster (1)
Horse (10)
Monkey (14)
Orangutan (3)
Pig (11)
Rabbit (10)
Sheep (8)
Application
IHC (76)
IHC-Fr (10)
IHC-P (38)
WB (134)
Flo (1)
DB (1)
ELISA (53)
ICC (12)
IF (26)
IP (13)
Peptide-ELISA (10)
Host
rabbit (111)
mouse (35)
goat (6)
chicken (1)
rat (1)
sheep (4)
Isotype
IgG (67)
IgG1 (22)
IgG1,k (6)
IgG2a (1)
IgG2a,k (3)
IgG2b (1)
IgY (1)
Clonality
monoclonal mc (36)
polyclonal pc (122)
Clone
10C299 (1)
1853CT506.24.16 (1)
24.8 (1)
2A7 (1)
2B2D1, 2B2A11 (2)
2E4 (1)
2F6 (1)
3H9 (2)
5C2 (1)
AT1E10 (1)
BSB-114 (2)
PAT1E10A (1)
Syn 211 (1)
syn211 (4)
Format
AP Conjugated (2)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (9)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (9)
HRP Conjugated (9)
PE Conjugated (5)
Ready-to-Use (1)
Serum (1)
Unconjugated (113)
Epitope
aa23-140 (16)
C-Terminus (14)
aa5-140 (8)
60-140 aa (5)
aa1-140 (5)
pSer129 (5)
pTyr136 (5)
pTyr133 (4)
aa108-120 (3)
aa116-131 (3)
aa111-131 (2)
aa91-140 (2)
pTyr125 (2)
10-90 aa, N-terminal (1)
70-150 aa (1)
Asp119 (1)
Glu123 (1)
Internal (1)
Met127 (1)
N-Terminus (1)
aa104-133 (1)
aa116-113 (1)
aa129-140 (1)
aa61-140 (1)
aa61-95 (1)
aa70-119 (1)
aa75-104 (1)
aa86-135 (1)
aa91-102 (1)
aa92-125 (1)
aa97-110 (1)
nTyr123/Tyr133 (1)
pS129 (1)
pSer 87 (1)
pSer87 (1)
Publications
No (158)
Publications
Showing 1-25 of 158 results

SNCA / Alpha-Synuclein Antibody (aa1-140, clone 5C2) IHC-plus™ LS-B2923
Mouse Monoclonal [clone 5C2] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
ELISA IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
The recombinant human synuclein family (a-, beta-and ?-) and a-synuclein domains (1-60, 1-95, 61-140 and 96-140) proteins were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-a-Synuclein (61-95 aa) antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

SNCA / Alpha-Synuclein Antibody (C-Terminus) IHC-plus™ LS-B10932
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IHC IHC-P IP WB
Unconjugated
50µl  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C153370
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IF WB
Unconjugated
100µg 1mg/ml  $365.00

SNCA / Alpha-Synuclein Antibody (phospho-S129) LS-C380861
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

SNCA / Alpha-Synuclein Antibody (phospho-Ser87) LS-C153371
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human
ELISA IHC WB
Unconjugated
100µg 100µl 1mg/ml  $345.00

SNCA / Alpha-Synuclein Antibody (N-Terminus) LS-C352877
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Chicken, Sheep, Mouse, Dog, Rat, Pig, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of Alpha-synuclein expression in A549 (A); SKNSH (B); PC12 (C) whole cell lysates.

SNCA / Alpha-Synuclein Antibody LS-C26325
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Mouse, Human
ELISA ICC IF IHC IHC-P WB
Unconjugated
100µg  $635.00

SNCA / Alpha-Synuclein Antibody (aa61-95, clone 10C299) LS-C132349
Mouse Monoclonal [clone 10C299] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
ELISA WB
Unconjugated
50µl  $375.00; 100µl 1mg/ml  $465.00

SNCA / Alpha-Synuclein Antibody (HRP) LS-C212005
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

SNCA / Alpha-Synuclein Antibody (aa91-102) IHC-plus™ LS-B11185
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Hamster, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
SNCA antibody (0.1 ug/ml) staining of fetal Mouse Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SNCA / Alpha-Synuclein Antibody LS-C204587
Chicken Polyclonal (IgY) to Human SNCA / Alpha-Synuclein
Rat, Pig, Cow, Horse, Mouse, Human
ICC IF WB
Unconjugated
100µl 1mg/ml  $285.00
Mixed rat neuron-glial cultures stained with SNCA / Alpha-Synuclein antibody, polyclonal antibody to alpha-synuclein (red) and monoclonal antibody to MAP2 4H5 (green). The alpha-synuclein antibody stains vesicular structures the perikarya and processes of the neurons in this image. Note that some of the neuronal perikarya contain much more alpha-synuclein than others. The blue channel shows the localization of DNA.
Blot of SNCA / Alpha-Synuclein antibody on crude extract of rat brain, showing strong band at 15 kDa.

SNCA / Alpha-Synuclein Antibody (clone syn211) LS-C87806
Mouse Monoclonal [clone syn211] (IgG1) to Human SNCA / Alpha-Synuclein
Human
IP WB
Unconjugated
100µl 200µg/ml  $295.00; 500µl 200µg/ml  $620.00; 1ml 200µg/ml  $935.00

SNCA / Alpha-Synuclein Antibody (clone syn211, Azide-free) LS-C87807
Mouse Monoclonal [clone syn211] (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC IHC-P IP WB
Unconjugated, Azide-free
100µl 1mg/ml  $680.00; 200µl 1mg/ml  $995.00

SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C89937
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100µg  $495.00

SNCA / Alpha-Synuclein Antibody (phospho-Ser 87) LS-C209728
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
DB
Unconjugated
50µg 0.2mg/ml  $435.00

SNCA / Alpha-Synuclein Antibody IHC-plus™ LS-B12154
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

SNCA / Alpha-Synuclein Antibody (aa1-140, Biotin) LS-C370648
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
ELISA
Biotin Conjugated
50µg 0.25mg/ml  $285.00; 100µg  $385.00

SNCA / Alpha-Synuclein Antibody LS-C346299
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:100.
Immunofluorescence analysis of MCF7 cell using SNCA antibody. Blue: DAPI for nuclear staining.

SNCA / Alpha-Synuclein Antibody (60-140 aa) LS-C386302
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemistry of Synuclein-alpha antibody
Western blot of Synuclein-alpha antibody

SNCA / Alpha-Synuclein Antibody (aa97-110) IHC-plus™ LS-B11186
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Human, Monkey
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
SNCA antibody (0.1 ug/ml) staining of Human Amygdala lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SNCA / Alpha-Synuclein Antibody (aa116-131) LS-C39427
Rat Monoclonal (IgG2a) to Human SNCA / Alpha-Synuclein
Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
500µl  $495.00; 1ml  $680.00

SNCA / Alpha-Synuclein Antibody IHC-plus™ LS-B8654
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Rat, Human
IHC IHC-P
Unconjugated
250µl  $585.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

SNCA / Alpha-Synuclein Antibody (nTyr123/Tyr133, clone 24.8) IHC-plus™ LS-B7735
Mouse Monoclonal [clone 24.8] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Nitrated alpha-Synuclein antibody (24.8) - Western blot of (A) Nitrated alpha-Synuclein protein and (B) non-nitrated alpha-Synuclein protein.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SNCA / Alpha-Synuclein Antibody (C-Terminus, Serum) LS-C11497
Goat Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
ELISA IHC-P
Unconjugated, Serum
0.1ml  $385.00

SNCA / Alpha-Synuclein Antibody (aa91-140) IHC-plus™ LS-B7625
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Western blot analysis of lysates from HUVEC cells, using Synuclein Antibody. The lane on the right is blocked with the synthesized peptide.
Showing 1-25 of 158 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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