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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SNCA / Alpha-Synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1
Target Sequences: NM_000345 NP_000336.1 P37840

Publications (3)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852]

Filtered By: None
Target
SNCA / Alpha-Synuclein (169)
Reactivity
Human (140)
Mouse (79)
Rat (88)
Bovine (12)
Chicken (2)
Chimpanzee (3)
Cow (1)
Dog (12)
Gibbon (3)
Guinea pig (4)
Hamster (1)
Horse (10)
Monkey (14)
Orangutan (3)
Pig (11)
Rabbit (10)
Sheep (8)
Application
IHC (93)
IHC-Fr (10)
IHC-P (37)
WB (144)
Flo (2)
DB (1)
ELISA (50)
ICC (12)
IF (31)
IP (13)
Peptide-ELISA (11)
Host
rabbit (122)
mouse (35)
goat (6)
chicken (1)
rat (1)
sheep (4)
Isotype
IgG (93)
IgG1 (22)
IgG1,k (6)
IgG2a (1)
IgG2a,k (3)
IgG2b (1)
IgY (1)
Clonality
monoclonal mc (36)
polyclonal pc (133)
Clone
10C299 (1)
1853CT506.24.16 (1)
24.8 (1)
2A7 (1)
2B2D1, 2B2A11 (2)
2E4 (1)
2F6 (1)
3H9 (2)
5C2 (1)
AT1E10 (1)
BSB-114 (2)
KM51 (1)
Syn 211 (1)
syn211 (4)
Format
AP Conjugated (2)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (11)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (12)
HRP Conjugated (9)
PE Conjugated (5)
Ready-to-Use (1)
Unconjugated (119)
Epitope
aa23-140 (20)
C-Terminus (14)
aa5-140 (9)
pSer129 (7)
pTyr136 (6)
60-140 aa (5)
aa1-140 (5)
pTyr133 (5)
aa108-120 (3)
aa116-131 (3)
pTyr125 (3)
70-150 aa (2)
aa111-131 (2)
aa91-140 (2)
aa92-125 (2)
10-90 aa, N-terminal (1)
Asp119 (1)
Glu123 (1)
Internal (1)
Met127 (1)
N-Terminus (1)
Tyr125 (1)
aa104-133 (1)
aa116-113 (1)
aa127-131 (1)
aa129-140 (1)
aa131-135 (1)
aa134-138 (1)
aa61-140 (1)
aa61-95 (1)
aa70-119 (1)
aa75-104 (1)
aa86-135 (1)
aa91-102 (1)
aa97-110 (1)
nTyr123/Tyr133 (1)
pSer 87 (1)
pSer87 (1)
Publications
No (169)
Publications
Showing 1-25 of 169 results

SNCA / Alpha-Synuclein Antibody (aa1-140, clone 5C2) IHC-plus™ LS-B2923
Mouse Monoclonal [clone 5C2] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
ELISA IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
The recombinant human synuclein family (a-, beta-and ?-) and a-synuclein domains (1-60, 1-95, 61-140 and 96-140) proteins were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-a-Synuclein (61-95 aa) antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C153370
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IF WB
Unconjugated
100µg 1mg/ml  $365.00

SNCA / Alpha-Synuclein Antibody (phospho-Ser87) LS-C153371
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µg 100µl 1mg/ml  $345.00

SNCA / Alpha-Synuclein Antibody (clone syn211) LS-C87806
Mouse Monoclonal [clone syn211] (IgG1) to Human SNCA / Alpha-Synuclein
Human
IP WB
Unconjugated
100µl 200µg/ml  $295.00; 500µl 200µg/ml  $620.00

SNCA / Alpha-Synuclein Antibody (clone syn211, Azide-free) LS-C87807
Mouse Monoclonal [clone syn211] (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC IHC-P IP WB
Unconjugated, Azide-free
100µl 1mg/ml  $680.00; 200µl 1mg/ml  $995.00

SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C89937
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100µg 1mg/ml  $495.00

SNCA / Alpha-Synuclein Antibody (HRP) LS-C212005
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg 0.42mg/ml  $385.00

SNCA / Alpha-Synuclein Antibody (aa134-138) LS-C205350
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IF WB
Unconjugated
50µl 1mg/ml  $355.00
Immunofluorescence of methanol-fixed HeLa cells using a-Synuclein (aa134-138) antibody.
Western blot of extracts from HeLa and 3T3 cells using a-Synuclein (aa134-138) antibody.

SNCA / Alpha-Synuclein Antibody IHC-plus™ LS-B12154
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
ELISA IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

SNCA / Alpha-Synuclein Antibody LS-C26325
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Mouse, Human
ELISA ICC IF IHC IHC-P WB
Unconjugated
100µg 0.5mg/ml  $605.00

SNCA / Alpha-Synuclein Antibody (APC) LS-C519442
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Human
ELISA ICC IF IHC WB
APC Conjugated
100µl  $800.00

SNCA / Alpha-Synuclein Antibody (AP) LS-C511525
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Human
ELISA ICC IF IHC WB
AP Conjugated
100µl  $800.00

SNCA / Alpha-Synuclein Antibody (aa1-140, Biotin) LS-C370648
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
ELISA
Biotin Conjugated
50µg 0.25mg/ml  $285.00; 100µg  $385.00

SNCA / Alpha-Synuclein Antibody (aa91-102) IHC-plus™ LS-B11185
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Hamster, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
SNCA antibody (0.1 ug/ml) staining of fetal Mouse Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SNCA / Alpha-Synuclein Antibody (C-Terminus) IHC-plus™ LS-B10932
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IHC IHC-P IP WB
Unconjugated
50µl  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SNCA / Alpha-Synuclein Antibody (aa116-131) LS-C39427
Rat Monoclonal (IgG2a) to Human SNCA / Alpha-Synuclein
Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
500µl  $485.00; 1000µl  $575.00

SNCA / Alpha-Synuclein Antibody IHC-plus™ LS-B8654
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Rat, Human
IHC IHC-P
Unconjugated
250µl  $585.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.

SNCA / Alpha-Synuclein Antibody (nTyr123/Tyr133, clone 24.8) IHC-plus™ LS-B7735
Mouse Monoclonal [clone 24.8] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Nitrated alpha-Synuclein antibody (24.8) - Western blot of (A) Nitrated alpha-Synuclein protein and (B) non-nitrated alpha-Synuclein protein.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C205089
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IF WB
Unconjugated
50µl 1mg/ml  $355.00
Immunofluorescence of methanol-fixed HeLa cells using a-Synuclein (Phospho-Tyr136) antibody.
Western blot of extracts from mouse brain tissue using a-Synuclein (Phospho-Tyr136) antibody and the same antibody preincubated with blocking peptide.

SNCA / Alpha-Synuclein Antibody (aa91-140) IHC-plus™ LS-B7625
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Western blot analysis of lysates from HUVEC cells, using Synuclein Antibody. The lane on the right is blocked with the synthesized peptide.

SNCA / Alpha-Synuclein Antibody (aa97-110) IHC-plus™ LS-B11186
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Human, Monkey
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-SNCA / Alpha-Synuclein antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
SNCA antibody (0.1 ug/ml) staining of Human Amygdala lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C358341
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Sheep, Bovine, Rat, Human, Monkey
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemical analysis of Alpha-synuclein (pS129) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Alpha-synuclein (pS129) staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C358869
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Rabbit, Mouse, Sheep, Bovine, Rat, Pig, Human, Monkey
ICC IF IHC IHC-P WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunohistochemical analysis of Alpha-synuclein staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Alpha-synuclein staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

SNCA / Alpha-Synuclein Antibody (Tyr125) LS-C34445
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
WB
Unconjugated
50µl 1mg/ml  $355.00
Western blot of extracts from Mouse Brain tissue using a-Synuclein(Ab-125) antibody.

SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C205262
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Mouse, Rat, Human
WB
Unconjugated
50µl 1mg/ml  $355.00
Western blot of extracts from mouse brain tissue using a-Synuclein (Phospho-Ser129) antibody (Lane 2) and the same antibody preincubated with blocking peptide (Lane1).
Showing 1-25 of 169 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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