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Unfortunately, the antibody LS-C212013 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



SNCA / Alpha-Synuclein Antibodies

synuclein, alpha (non A4 component of amyloid precursor)

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA Antibody, Alpha-synuclein Antibody, PARK4 Antibody, PD1 Antibody, Synuclein alpha-140 Antibody, NACP Antibody, PARK1 Antibody
Target Sequences: NM_000345 NP_000336.1 P37840
 SNCA / Alpha-Synuclein Feature Table
Featured Image

Featured SNCA / Alpha-Synuclein Antibody

LS-B7625 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (3)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131] Related Antibodies: LS-B7735.
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852] Related Antibodies: LS-B7735.

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, ELISA aa91-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa91-140) IHC-plus™ LS-B7625
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C153370
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB, IP C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) IHC-plus™ LS-B10932
IHC Image
IHC Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1,k Monoclonal 5C2 Unconjugated Human IHC-P, WB, ELISA aa1-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa1-140, clone 5C2) IHC-plus™ LS-B2923
IHC Image
WB Image
Mouse Monoclonal [clone 5C2] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Goat Polyclonal Unconjugated Human, Monkey IHC-P, WB, ELISA Internal No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Internal) IHC-plus™ LS-B11186
IHC Image
WB Image
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Human, Monkey
IHC - Paraffin, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Goat Polyclonal Unconjugated Human, Mouse, Hamster IHC-P, WB, ELISA Internal No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Internal) IHC-plus™ LS-B11185
IHC Image
WB Image
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Hamster
IHC - Paraffin, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1,k Monoclonal 24.8 Unconjugated Human IHC-P, WB nTyr123/Tyr133 Yes Primary
Anti-SNCA / Alpha-Synuclein Antibody (nTyr123/Tyr133, clone 24.8) IHC-plus™ LS-B7735
PublicationsPublications (2)
IHC Image
WB Image
Mouse Monoclonal [clone 24.8] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Rat IHC-P No Primary
Anti-SNCA / Alpha-Synuclein Antibody IHC-plus™ LS-B8654
IHC Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Rat
IHC - Paraffin
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1,k Monoclonal Unconjugated Human IHC-P, WB, IP, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody IHC-plus™ LS-B11846
IHC Image
Mouse Monoclonal (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human IHC-P, WB C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C99183
IHC Image
IHC Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse Monoclonal 2B2D1, 2B2A11 Unconjugated Human IHC, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone 2B2D1, 2B2A11) LS-C47174
IHC Image
WB Image
Mouse Monoclonal [clone 2B2D1, 2B2A11] to Human SNCA / Alpha-Synuclein
Human
IHC, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB Asp119 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Asp119) LS-C177499
IHC Image
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB Glu123 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Glu123) LS-C176470
IHC Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Rat IHC C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C50558
IHC Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Rat
IHC
Unconjugated
SNCA / Alpha-Synuclein Mouse Monoclonal Unconjugated Human IHC-P, IHC-Fr, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C89936
Mouse Monoclonal to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal Unconjugated Human IHC-P, IHC-Fr, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C39442
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rat IgG2a Monoclonal Unconjugated Human IHC-P, IHC-Fr, WB, IP aa116-131 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa116-131) LS-C39427
Rat Monoclonal (IgG2a) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Rat IHC-P, IHC-Fr, WB aa111-131 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa111-131) LS-C39430
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Rat
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
SNCA / Alpha-Synuclein Sheep IgG Polyclonal Unconjugated Human, Rat IHC-P, IHC-Fr, WB aa116-131 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa116-131) LS-C39424
Sheep Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Rat
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Rabbit IHC-P, IHC-Fr, WB aa129-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa129-140) LS-C89931
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Rabbit
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Rat IHC-P, IHC-Fr, WB aa111-131 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa111-131) LS-C39429
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Rat
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
SNCA / Alpha-Synuclein Sheep IgG Polyclonal Unconjugated Human, Mouse, Rat IHC-P, IHC-Fr aa108-120 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa108-120) LS-C39423
Sheep Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC - Paraffin, IHC - Frozen
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB pTyr133 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr133) LS-C336085
IF Image
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal Syn 211 Unconjugated Human IHC, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone Syn 211) LS-C26941
WB Image
Mouse Monoclonal [clone Syn 211] (IgG1)
Human
IHC, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C330763
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB, ELISA C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C336198
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (FITC) LS-C212012
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
IHC, Western blot, ELISA
FITC Conjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA pSer87 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser87) LS-C153371
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C153369
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal syn211 Unconjugated, Azide-free Human IHC-P, WB, IP No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone syn211, Azide-free) LS-C87807
Mouse Monoclonal [clone syn211] (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated, Azide-free
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C212004
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
IHC, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal HRP Conjugated Human IHC, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (HRP) LS-C212005
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
IHC, Western blot, ELISA
HRP Conjugated
SNCA / Alpha-Synuclein Goat Polyclonal Unconjugated Human IHC, ELISA C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C84160
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Human
IHC, ELISA
Unconjugated
SNCA / Alpha-Synuclein Goat IgG Polyclonal Unconjugated Human IHC-P, ELISA C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C11497
Goat Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, ELISA pTyr125 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr125) LS-C286249
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC, WB Met127 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Met127) LS-C192093
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
IHC, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG Monoclonal Unconjugated Human, Mouse IHC-P, ICC, IF, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C26325
Mouse Monoclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse
IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal Unconjugated Human IHC-P, WB, IP No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C76181
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal Unconjugated Human IHC-P, WB, IP C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C39434
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal Unconjugated Human IHC-P, WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C39432
Mouse Monoclonal (IgG1) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse Monoclonal Unconjugated Human IHC, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C39426
Mouse Monoclonal to Human SNCA / Alpha-Synuclein
Human
IHC, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG Monoclonal Unconjugated Human IHC-Fr, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C39431
Mouse Monoclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
IHC - Frozen, Western blot
Unconjugated
SNCA / Alpha-Synuclein Goat IgG Polyclonal Unconjugated Human IHC-P, ELISA C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C39435
Goat Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1,k Monoclonal KM51 Unconjugated Human IHC-P No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone KM51) LS-C189586
Mouse Monoclonal [clone KM51] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
IHC - Paraffin
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Rat IHC-P C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C122463
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Rat
IHC - Paraffin
Unconjugated
SNCA / Alpha-Synuclein Sheep Polyclonal Unconjugated Human, Monkey, Bovine, Dog, Horse IHC aa116-113 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa116-113) LS-C89932
Sheep Polyclonal to Human SNCA / Alpha-Synuclein
Human, Monkey, Bovine, Dog, Horse
IHC
Unconjugated
SNCA / Alpha-Synuclein Sheep Polyclonal Unconjugated Human, Mouse, Rat, Dog IHC aa108-120 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa108-120) LS-C89926
Sheep Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat, Dog
IHC
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG2a,k Monoclonal 2E4 Unconjugated Human WB, IP, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone 2E4) LS-C198233
WB Image
IP Image
Mouse Monoclonal [clone 2E4] (IgG2a,k) to Human SNCA / Alpha-Synuclein
Human
Western blot, Immunoprecipitation, ELISA
Unconjugated
SNCA / Alpha-Synuclein Chicken IgY Polyclonal Unconjugated Human ICC, IF, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C204587
ICC Image
WB Image
Chicken Polyclonal (IgY) to Human SNCA / Alpha-Synuclein
Human
ICC, Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal 3H9 Unconjugated Human ICC, IF, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone 3H9) LS-C204586
ICC Image
WB Image
Mouse Monoclonal [clone 3H9] (IgG1) to Human SNCA / Alpha-Synuclein
Human
ICC, Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal 2A7 Unconjugated Human ICC, IF, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone 2A7) LS-C204583
ICC Image
WB Image
Mouse Monoclonal [clone 2A7] (IgG1) to Human SNCA / Alpha-Synuclein
Human
ICC, Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Mouse, Rat IF, WB aa134-138 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa134-138) LS-C205350
IF Image
WB Image
Rabbit Polyclonal to Mouse SNCA / Alpha-Synuclein
Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human IF, WB pTyr125 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr125) LS-C335898
IF Image
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF, WB pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C335908
IF Image
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IF, WB pTyr133 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr133) LS-C205275
IF Image
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IF, WB pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C205089
IF Image
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat IF, WB aa131-135 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa131-135) LS-C205168
IF Image
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human IF, WB pTyr125 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr125) LS-C205272
IF Image
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human WB C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C99188
WB Image
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human
Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1,k Monoclonal AT1E10 Unconjugated Human WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone AT1E10) LS-C200827
WB Image
Mouse Monoclonal [clone AT1E10] (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA aa70-119 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa70-119) LS-C200739
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa5-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa5-140) LS-C296564
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Rat WB, ELISA aa23-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa23-140) LS-C296567
WB Image
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA aa23-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa23-140) LS-C296566
WB Image
Rabbit Polyclonal (IgG) to Mouse SNCA / Alpha-Synuclein
Mouse
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA aa91-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa91-140) LS-C199632
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA pTyr133 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr133) LS-C117492
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA aa86-135 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa86-135) LS-C118261
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C117493
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit Monoclonal EPR2179(2) Unconjugated Human ICC, WB pTyr125 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr125, clone EPR2179(2)) LS-C138699
WB Image
Rabbit Monoclonal [clone EPR2179(2)] to Human SNCA / Alpha-Synuclein
Human
ICC, Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal 3H9 Unconjugated Human, Mouse, Rat IF, WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone 3H9) LS-C150325
WB Image
Mouse Monoclonal [clone 3H9] (IgG1) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Sheep WB C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C110685
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Sheep
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C205262
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human WB Tyr125 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Tyr125) LS-C34445
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Dog WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C53469
WB Image
Rabbit Polyclonal
Human, Mouse, Rat, Bovine, Dog
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C203603
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C336079
WB Image
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB aa127-131 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa127-131) LS-C205340
WB Image
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG2b Monoclonal 2F6 Unconjugated Human WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone 2F6) LS-C174791
WB Image
Mouse Monoclonal [clone 2F6] (IgG2b) to Human SNCA / Alpha-Synuclein
Human
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Rat WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C319025
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal FITC Conjugated Rat WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (FITC) LS-C318571
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot, ELISA
FITC Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA aa5-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa5-140, Biotin) LS-C299075
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Western blot, ELISA
Biotin Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Biotin Conjugated Rat WB, ELISA aa23-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa23-140, Biotin) LS-C299078
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot, ELISA
Biotin Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Biotin Conjugated Mouse WB, ELISA aa23-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa23-140, Biotin) LS-C299076
Rabbit Polyclonal (IgG) to Mouse SNCA / Alpha-Synuclein
Mouse
Western blot, ELISA
Biotin Conjugated
SNCA / Alpha-Synuclein Mouse IgG1 Monoclonal syn211 Unconjugated Human WB, IP No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone syn211) LS-C87806
Mouse Monoclonal [clone syn211] (IgG1) to Human SNCA / Alpha-Synuclein
Human
Western blot, Immunoprecipitation
Unconjugated
SNCA / Alpha-Synuclein Goat Polyclonal Unconjugated Human WB, ELISA aa116-131 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa116-131) LS-C86301
Goat Polyclonal to Human SNCA / Alpha-Synuclein
Human
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C286270
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Biotin Conjugated Rat WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Biotin) LS-C318570
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot, ELISA
Biotin Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal HRP Conjugated Rat WB, ELISA No Primary
Anti-SNCA / Alpha-Synuclein Antibody (HRP) LS-C318140
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot, ELISA
HRP Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human DB pSer 87 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser 87) LS-C209728
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Dot Blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human DB Ser87 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Ser87) LS-C209731
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Dot Blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C192202
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal FITC Conjugated Human WB aa5-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa5-140, FITC) LS-C303115
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Western blot
FITC Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal FITC Conjugated Rat WB aa23-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa23-140, FITC) LS-C303117
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot
FITC Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal FITC Conjugated Mouse WB aa23-140 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa23-140, FITC) LS-C303118
Rabbit Polyclonal (IgG) to Mouse SNCA / Alpha-Synuclein
Mouse
Western blot
FITC Conjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA C-Terminus No Primary
Anti-SNCA / Alpha-Synuclein Antibody (C-Terminus) LS-C26323
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG1,k Monoclonal Unconjugated Human WB, ELISA aa61-95 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa61-95) LS-C132349
Mouse Monoclonal (IgG1,k) to Human SNCA / Alpha-Synuclein
Human
Western blot, ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF pTyr133 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr133) LS-C189425
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human DB pSer87 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser87) LS-C189224
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Dot Blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human DB Ser87 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (Ser87) LS-C189223
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human
Dot Blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Rat WB pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C189428
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C189427
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IF pTyr136 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Tyr136) LS-C189426
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat
Immunofluorescence
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Rat WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C132346
Rabbit Polyclonal (IgG) to Rat SNCA / Alpha-Synuclein
Rat
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Dog ELISA aa108-120 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (aa108-120) LS-C89938
Rabbit Polyclonal to Human SNCA / Alpha-Synuclein
Human, Mouse, Rat, Dog
ELISA
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit WB pSer129 No Primary
Anti-SNCA / Alpha-Synuclein Antibody (phospho-Ser129) LS-C89937
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit
Western blot
Unconjugated
SNCA / Alpha-Synuclein Mouse IgG2a,k Monoclonal SPM301 Unconjugated Human WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody (clone SPM301) LS-C189222
Mouse Monoclonal [clone SPM301] (IgG2a,k) to Human SNCA / Alpha-Synuclein
Human
Western blot
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit IF No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C132351
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit
Immunofluorescence
Unconjugated
SNCA / Alpha-Synuclein Rabbit IgG Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit, Chicken WB No Primary
Anti-SNCA / Alpha-Synuclein Antibody LS-C132350
Rabbit Polyclonal (IgG) to Human SNCA / Alpha-Synuclein
Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit, Chicken
Western blot
Unconjugated
Target Corresponding Antibodies
SNCA / Alpha-Synuclein
SNCA / Alpha-Synuclein Antibody Blocking Peptide - LS-E8221
LS-E8221
SNCA / Alpha-Synuclein
LS-C99183
SNCA / Alpha-Synuclein
SNCA / Alpha-Synuclein Antibody Blocking Peptide - LS-E8224
LS-E8224
SNCA / Alpha-Synuclein
LS-C99188
SNCA / Alpha-Synuclein
SNCA / Alpha-Synuclein Antibody Blocking Peptide - LS-E27971
LS-E27971
SNCA / Alpha-Synuclein
LS-B11185
SNCA / Alpha-Synuclein
SNCA / Alpha-Synuclein Antibody Blocking Peptide - LS-E27972
LS-E27972
SNCA / Alpha-Synuclein
LS-B11186
Type Target Reactivity Sample Type
Cell-Based Phosphorylation SNCA / Alpha-Synuclein Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat Phospho-SNCA / Alpha-Synuclein (Ser129) Cell-Based ELISA Kit - LS-F1227
Cell-Based Phosphorylation
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
Cell-Based Phosphorylation SNCA / Alpha-Synuclein Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat Phospho-SNCA / Alpha-Synuclein (Tyr133) Cell-Based ELISA Kit - LS-F1634
Cell-Based Phosphorylation
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
Cell-Based Phosphorylation SNCA / Alpha-Synuclein Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat Phospho-SNCA / Alpha-Synuclein (Tyr136) Cell-Based ELISA Kit - LS-F1635
Cell-Based Phosphorylation
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
Cell-Based SNCA / Alpha-Synuclein Mouse, Human, Rat Adherent Cell Cultures
Mouse/Human/Rat SNCA / Alpha-Synuclein Cell-Based ELISA Kit - LS-F2342
Cell-Based
Mouse, Human, Rat
96-Well Microplate with Colorimetric - 450nm detection type
Adherent Cell Cultures
Sandwich SNCA / Alpha-Synuclein Human Cerebrospinal Fluid, Plasma, Serum
Human SNCA / Alpha-Synuclein ELISA Kit - LS-F4486
Sandwich
Human
96-Well Strip Plate with Colorimetric - 450nm detection type
Cerebrospinal Fluid, Plasma, Serum
Sandwich SNCA / Alpha-Synuclein Mouse Plasma, Serum, Tissue Homogenates
Mouse SNCA / Alpha-Synuclein ELISA Kit - LS-F6284
Sandwich
Mouse
96-Well Strip Plate with Colorimetric - 450nm detection type
Plasma, Serum, Tissue Homogenates
Sandwich SNCA / Alpha-Synuclein Rat Plasma, Serum, Tissue Homogenates
Rat SNCA / Alpha-Synuclein ELISA Kit - LS-F9636
Sandwich
Rat
96-Well Strip Plate with Colorimetric - 450nm detection type
Plasma, Serum, Tissue Homogenates

SNCA / Alpha-Synuclein Feature Table


Feature Type Location Details
alternative products 1 - 140 Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist; Name=1; Synonyms=NACP140; IsoId=P37840-1; Sequence=Displayed; Name=2-4; Synonyms=NACP112; IsoId=P37840-2; Sequence=VSP_006364; Name=2-5; IsoId=P37840-3; Sequence=VSP_006363;
Disease 1 - 140 Defects in SNCA are the cause of dementia Lewy body (DLB) [MIM:127750]. A neurodegenerative disorder clinically characterized by mental impairment leading to dementia, parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Brainstem or cortical intraneuronal accumulations of aggregated proteins (Lewy bodies) are the only essential pathologic features. Patients may also have hippocampal and neocortical senile plaques, sometimes in sufficient number to fulfill the diagnostic criteria for Alzheimer disease.
Disease 1 - 140 Defects in SNCA are the cause of Parkinson disease type 1 (PARK1) [MIM:168601]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Fami
Disease 1 - 140 Defects in SNCA are the cause of Parkinson disease type 4 (PARK4) [MIM:605543]. A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.
domain 1 - 140 The NAC domain is involved in the fibril formation. The middle region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments.
Function 1 - 140 May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
miscellaneous 1 - 140 SNCA is found as a minor component within amyloid deposits in Alzheimer disease. It is also found within Lewy body (LB)-like intraneuronal inclusions, glial inclusions and axonal spheroids in neurodegeneration with brain iron accumulation type 1.
ptm 1 - 140 Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.
ptm 1 - 140 Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.
ptm 1 - 140 Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).
Similarity 1 - 140 Belongs to the synuclein family.
Subcellular Location 1 - 140 Cytoplasm. Membrane. Nucleus. Note=Membrane- bound in dopaminergic neurons. Also found in the nucleus.
Subunit 1 - 140 Soluble monomer which can form filamentous aggregates. Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones.
Tissue Specificity 1 - 140 Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
web resource 1 - 140 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SNCA";
web resource 1 - 140 Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/snca/";
arrayexpress 1 - 140 P37840
bgee 1 - 140 P37840
cleanex 1 - 140 HS_SNCA
ctd 1 - 140 6622
dip 1 - 140 DIP-35354N
dip 1 - 140 DIP-46126N
disprot 1 - 140 DP00070
doi 1 - 140 10
drugbank 1 - 140 DB01065
eggnog 1 - 140 prNOG21039
embl 1 - 140 AF163864
embl 1 - 140 AK290169
embl 1 - 140 AY049786
embl 1 - 140 BC013293
embl 1 - 140 BC108275
embl 1 - 140 CH471057
embl 1 - 140 CR457058
embl 1 - 140 D31839
embl 1 - 140 DQ088379
embl 1 - 140 L08850
embl 1 - 140 L36674
embl 1 - 140 L36675
embl 1 - 140 U46897
embl 1 - 140 U46898
embl 1 - 140 U46899
embl 1 - 140 U46901
ensembl 1 - 140 ENST00000336904
ensembl 1 - 140 ENST00000394986
ensembl 1 - 140 ENST00000394991
gene3d 1 - 140 G3DSA:1.10.287.700
genecards 1 - 140 GC04M090646
geneid 1 - 140 6622
genevestigator 1 - 140 P37840
germonline 1 - 140 ENSG00000145335
go 1 - 140 GO:0000287
go 1 - 140 GO:0001921
go 1 - 140 GO:0005509
go 1 - 140 GO:0005634
go 1 - 140 GO:0005829
go 1 - 140 GO:0005886
go 1 - 140 GO:0005938
go 1 - 140 GO:0006916
go 1 - 140 GO:0008198
go 1 - 140 GO:0008219
go 1 - 140 GO:0008270
go 1 - 140 GO:0010040
go 1 - 140 GO:0010517
go 1 - 140 GO:0010642
go 1 - 140 GO:0015629
go 1 - 140 GO:0019894
go 1 - 140 GO:0030424
go 1 - 140 GO:0030426
go 1 - 140 GO:0030544
go 1 - 140 GO:0031623
go 1 - 140 GO:0032026
go 1 - 140 GO:0032410
go 1 - 140 GO:0032496
go 1 - 140 GO:0032769
go 1 - 140 GO:0034341
go 1 - 140 GO:0035067
go 1 - 140 GO:0042393
go 1 - 140 GO:0043014
go 1 - 140 GO:0043027
go 1 - 140 GO:0043154
go 1 - 140 GO:0043205
go 1 - 140 GO:0043274
go 1 - 140 GO:0045502
go 1 - 140 GO:0045807
go 1 - 140 GO:0045920
go 1 - 140 GO:0048156
go 1 - 140 GO:0048488
go 1 - 140 GO:0051281
go 1 - 140 GO:0051585
go 1 - 140 GO:0051612
go 1 - 140 GO:0051622
go 1 - 140 GO:0060732
go 1 - 140 GO:0070495
go 1 - 140 GO:0070555
h-invdb 1 - 140 HIX0004376
hgnc 1 - 140 HGNC:11138
hogenom 1 - 140 HBG715579
hovergen 1 - 140 HBG000481
inparanoid 1 - 140 P37840
interpro 1 - 140 IPR001058
interpro 1 - 140 IPR002460
ipi 1 - 140 IPI00024107
ipi 1 - 140 IPI00218467
ipi 1 - 140 IPI00218468
kegg 1 - 140 hsa:6622
medline 1 - 140 20085057
medline 1 - 140 20409007
medline 1 - 140 21922879
medline 1 - 140 22445249
medline 1 - 140 22744261
medline 1 - 140 22744269
medline 1 - 140 94068588
medline 1 - 140 95100969
medline 1 - 140 95324916
medline 1 - 140 97342853
medline 1 - 140 98122567
mim 1 - 140 127750
mim 1 - 140 163890
mim 1 - 140 168600
mim 1 - 140 168601
mim 1 - 140 605543
mint 1 - 140 MINT-2515483
nextbio 1 - 140 25791
oma 1 - 140 PENEAYE
orphanet 1 - 140 2828
orphanet 1 - 140 33540
orthodb 1 - 140 EOG9ZPHF6
panther 1 - 140 PTHR13820
pathway_interaction_db 1 - 140 alphasynuclein_pathway
pdb 1 - 140 1XQ8
pdb 1 - 140 2JN5
pdb 1 - 140 2KKW
pdb 1 - 140 2X6M
pdbsum 1 - 140 1XQ8
pdbsum 1 - 140 2JN5
pdbsum 1 - 140 2KKW
pdbsum 1 - 140 2X6M
pfam 1 - 140 PF01387
pharmgkb 1 - 140 PA35986
phosphosite 1 - 140 P37840
phylomedb 1 - 140 P37840
pir 1 - 140 A49669
pir 1 - 140 S56746
pmap-cutdb 1 - 140 P37840
pride 1 - 140 P37840
prints 1 - 140 PR01211
prints 1 - 140 PR01212
proteinmodelportal 1 - 140 P37840
pubmed 1 - 140 10617630
pubmed 1 - 140 10852916
pubmed 1 - 140 11156617
pubmed 1 - 140 11821392
pubmed 1 - 140 12558071
pubmed 1 - 140 12859192
pubmed 1 - 140 12859200
pubmed 1 - 140 12893833
pubmed 1 - 140 14702039
pubmed 1 - 140 14755719
pubmed 1 - 140 15489334
pubmed 1 - 140 15498564
pubmed 1 - 140 15615727
pubmed 1 - 140 7601450
pubmed 1 - 140 7802671
pubmed 1 - 140 8248242
pubmed 1 - 140 9197268
pubmed 1 - 140 9462735
refseq 1 - 140 NP_000336.1
refseq 1 - 140 NP_001139526.1
refseq 1 - 140 NP_001139527.1
refseq 1 - 140 NP_009292.1
string 1 - 140 P37840
tcdb 1 - 140 1.C.77.1.1
ucsc 1 - 140 uc003hso.1
ucsc 1 - 140 uc003hsp.1
ucsc 1 - 140 uc010ikt.1
unigene 1 - 140 Hs.21374
joined; genomic_dna 1 - 140 AAC02114.1
chain 1 - 140 Alpha-synuclein /FTId=PRO_0000184022.
Modification 87 - 87 Phosphoserine; by CK2
Modification 125 - 125 Phosphotyrosine
Modification 129 - 129 Phosphoserine; by BARK1, CK2 and GRK5
mutagen 39 - 39 Y->F: No effect on osmotic stress-induced phosphorylation.
mutagen 125 - 125 Y->F: Abolishes osmotic stress-induced phosphorylation.
mutagen 133 - 133 Y->F: No effect on osmotic stress-induced phosphorylation.
mutagen 136 - 136 Y->F: No effect on osmotic stress-induced phosphorylation.
region 20 - 67 4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).
repeat 20 - 30 1
repeat 31 - 41 2
repeat 42 - 56 3; approximate
repeat 57 - 67 4
var_seq 41 - 54 Missing (in isoform 2-5) /FTId=VSP_006363.
var_seq 103 - 130 Missing (in isoform 2-4) /FTId=VSP_006364.
variant 30 - 30 A -> P (in PARK1) /FTId=VAR_007957.
variant 46 - 46 E -> K (in PARK1 and DLB; significant increase in binding to negatively charged phospholipid liposomes). /FTId=VAR_022703.
variant 53 - 53 A -> T (in PARK1; no effect on osmotic stress-induced phosphorylation). /FTId=VAR_007454.
keyword 1 - 140 3D-structure
keyword 1 - 140 Alternative splicing
keyword 1 - 140 Alzheimer disease
keyword 1 - 140 Amyloid
keyword 1 - 140 Complete proteome
keyword 1 - 140 Cytoplasm
keyword 1 - 140 Direct protein sequencing
keyword 1 - 140 Disease mutation
keyword 1 - 140 Membrane
keyword 1 - 140 Neurodegeneration
keyword 1 - 140 Nucleus
keyword 1 - 140 Parkinson disease
keyword 1 - 140 Parkinsonism
keyword 1 - 140 Phosphoprotein
keyword 1 - 140 Repeat
keyword 1 - 140 Ubl conjugation
Molecular Weight 1 - 140 14460
1 hit 1 - 140 PF01387

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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