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SNCA / Alpha-Synuclein

synuclein, alpha (non A4 component of amyloid precursor)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene Name: synuclein, alpha (non A4 component of amyloid precursor)
Synonyms: SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1, aSynuclein, a-Synuclein
Target Sequences: NM_000345 NP_000336.1 P37840

Publications (7)

1
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Science (New York, N.Y.). 2000 290:985-9. [PubMed:11062131]
2
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Qing H, Wong W, McGeer EG, McGeer PL. Biochemical and biophysical research communications. 2009 387:149-52. (WB) [PubMed:19576176]
3
Determining nuclear localization of alpha-synuclein in mouse brains. Huang Z, Xu Z, Wu Y, Zhou Y. Neuroscience. 2011 199:318-32. [PubMed:22033456] [PMC:PMC3237852]
4
Reversible Conformational Conversion of a-Synuclein into Toxic Assemblies by Glucosylceramide. Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR. Neuron. 2018 January;97:92-107. [Full Text Article] [PubMed:29290548] [PMC:PMC6013314]
5
Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. Mélissa Jasmin, Eun Hee Ahn, Merja H Voutilainen, Joanna Fombonne, Catherine Guix, Tuulikki Viljakainen, Seong Su Kang, Li-Ying Yu, Mart Saarma, Patrick Mehlen, Keqiang Ye. The EMBO journal. 2021 February;40:e105537. [Full Text Article] [PubMed:33351190] [PMC:PMC7849168] Related Antibodies: LS-C380861.
6
Facile single-molecule pull-down assay for analysis of endogenous proteins. Benjamin Croop, Kyu Young Han. Physical biology. 2019 March;16:035002. [Full Text Article] [PubMed:30769341] [PMC:PMC9238377] Related Antibodies: LS-C370648.
7
UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 March;9:e2103396. [Full Text Article] [PubMed:35023303] [PMC:PMC8895126] Related Antibodies: LS-C380861.
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Products
Proteins (51)
Over-Expression Lysate (8)
Recombinant (43)
SNCA / Alpha-Synuclein (51)
No (51)
6His, N-terminus (5)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (2)
His (4)
His, N-Terminal (1)
Myc-DDK (Flag) (12)
Crab-eating macaque (1)
Cynomolgus monkey (1)
Human (35)
Mouse (8)
Rat (2)
293T Cells (4)
E. coli (35)
HEK 293 Cells (8)
Wheat Germ Extract (2)
Yeast (2)
Purified (7)
Low endotoxin level (11)
SNCA / Alpha-Synuclein Protein
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Yeast
6His, N-terminus
16.5 kD
500 µg/$1,411; 100 µg/$679; 20 µg/$429
SNCA / Alpha-Synuclein Protein
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E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
SNCA / Alpha-Synuclein Protein
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$311; 20 µg/$245; 1 mg/$511
SNCA / Alpha-Synuclein Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
41.5 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SNCA / Alpha-Synuclein Protein
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Yeast
His
16.5 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
14.3 kDa
100 µg/$494
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
14.3 kDa
100 µg/$494
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.7 kDa
10 µg/$248; 50 µg/$288
SNCA / Alpha-Synuclein Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
11.2 kDa
100 µg/$494
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E. coli
None
14.3 kDa
100 µg/$677
SNCA / Alpha-Synuclein Protein - Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Preformed Fibrils at 4 µg/ml (D-F), but not when treated with Type 2 Alpha Synuclein Preformed Fibrils at 4 µg/ml (A-C). Tissue: Primary hippocampal neurons. Species: Sprague-Dawley rat. Fixation: 4% formaldehyde made from PFA. Primary Antibody: Mouse anti-pSer129 Antibody at 1:1000 24 hours at 4°C. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:700 for 1 hours at RT. Counterstain: Hoechst (blue) nuclear stain at 1:4000 for 1 hour at RT. Localization: Lewy body inclusions. Magnification: 20x.
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E. coli
None
100 µg/$478; 200 µg/$702; 500 µg/$1,313
SNCA / Alpha-Synuclein Protein - SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Monomer. Lane 1: Molecular Weight Ladder (MW). Lane 2: BSA (2.5 µg). Lane 3: BSA (5 µg). Lane 4: Alpha Synuclein Protein Monomer (2.5 µg). Lane 5: Alpha Synuclein Protein Monomer (5 µg).
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E. coli
None
100 µg/$478; 200 µg/$702; 500 µg/$1,313
SNCA / Alpha-Synuclein Protein - 12.5% SDS-PAGE of human SNCA stained with Coomassie Blue
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Wheat Germ Extract
GST
41.14 kDa
10 µg/$479; 25 µg/$670
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
14.3 kDa
20 µg/$150
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
14.3 kDa
20 µg/$150
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
14.3 kDa
20 µg/$150
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
11.2 kDa
20 µg/$150
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
SNCA / Alpha-Synuclein Protein - Purified recombinant protein SNCA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
14.3 kDa
20 µg/$1,107
SNCA / Alpha-Synuclein Protein - Purified recombinant protein SNCA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
14.3 kDa
20 µg/$1,107
SNCA / Alpha-Synuclein Protein - Purified recombinant protein SNCA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
11.2 kDa
20 µg/$1,107
SNCA / Alpha-Synuclein Protein - Purified recombinant protein SNCA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
14.3 kDa
20 µg/$1,107
SNCA / Alpha-Synuclein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
14.3 kDa
100 µg/$494
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E. coli
None
14.5 kDa
100 µg/$451; 1 mg/$2,017
Viewing 1-25 of 51 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).