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SNAP25
synaptosomal-associated protein, 25kDa
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
| Gene Name: | synaptosomal-associated protein, 25kDa |
| Family/Subfamily: | SNAP-25 , Not assigned-Other |
| Synonyms: | SNAP25, BA416N4.2, DJ1068F16.2, SNAP, SUP, Super protein, RIC4, SEC9, SNAP-25, RIC-4 |
| Target Sequences: | NM_003081 NP_003072.2 P60880 |
Publications (3)
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