SNAI2 / SLUG

snail family zinc finger 2

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

SNAI2 / SLUG (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human SNAI2 / SLUG Protein (Recombinant GST, N-terminus) (aa97-169) - LS-G60139

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SNAI2 / SLUG Protein (Recombinant His, N-Terminal) - LS-G143862

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.4 kDa

Price:

50 µg/$419

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Human SNAI2 / SLUG Protein (Recombinant GST) (Full Length) - LS-G30459

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.4 kDa

Price:

2 µg/$439

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Human SNAI2 / SLUG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84227

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.8 kDa

Price:

20 µg/$150

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SNAI2 / SLUG Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99955

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.8 kDa

Price:

100 µg/$494

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Human SNAI2 / SLUG Protein (Recombinant His) - LS-G3295

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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