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SNAI1 / SNAIL-1

snail family zinc finger 1

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Gene Name: snail family zinc finger 1
Synonyms: SNAI1, DJ710H13.1, Protein sna, SNAIL, Snail 1, Snail 1, zinc finger protein, Snail homolog 1 (Drosophila), SNA, Snail 1 homolog, Protein snail homolog 1, SNAH, Snail 1 zinc finger protein, Zinc finger protein SNAI1, SLUGH2, SNAIL1
Target Sequences: NM_005985 NP_005976.2 O95863

Publications (5)

1
Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. De Vriese AS, Tilton RG, Mortier S, Lameire NH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 21:2549-55. [PubMed:16757496] Related Antibodies: LS-C97983.
2
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C176686.
3
Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis. Roth B, Jayaratna I, Sundi D, Cheng T, Melquist J, Choi W, Porten S, Nitti G, Navai N, Wszolek M, Guo C, Czerniak B, McConkey D, Dinney C. Oncotarget. 2017 8:34205-34222. (WB; Human) [Full Text Article] [PubMed:27494900] [PMC:PMC5470961]
4
3D hydrogel breast cancer models for studying the effects of hypoxia on epithelial to mesenchymal transition. Wang Y, Mirza S, Wu S, Zeng J, Shi W, Band H, Band V, Duan B. Oncotarget. 2018 August;9:32191-32203. [Full Text Article] [PubMed:30181809] [PMC:PMC6114943] Related Antibodies: LS-C176686.
5
Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. Nevi L, Costantini D, Safarikia S, Di Matteo S, Melandro F, Berloco PB, Cardinale V. Cells. 2019 November;8:E1443. [Full Text Article] [PubMed:31731674] [PMC:PMC6912632]
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Products
Antibodies (73)
Primary (73)
SNAI1 / SNAIL-1 (73)
Human (70)
Mouse (25)
Rat (12)
Chimpanzee (6)
Dog (1)
Guinea pig (4)
Horse (1)
Monkey (11)
Orangutan (3)
IHC (36)
IHC-P (14)
WB (64)
ELISA (23)
FLISA (1)
ICC (3)
IF (11)
Peptide-ELISA (4)
rabbit (59)
mouse (11)
goat (2)
rat (1)
Product Group
IHCPlus (5)
IgG (36)
IgG1 (7)
IgG2b (2)
IgG2b,k (2)
monoclonal mc (12)
polyclonal pc (61)
2G11 (1)
6D2 (2)
AT2D5 (1)
OTI10D7 (2)
OTI1H7 (2)
OTI5E12 (2)
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (6)
Carrier-free (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (50)
N-Terminus (9)
aa1-264 (8)
aa9-39 (8)
pSer246 (4)
190-270 aa (2)
aa1-30 (2)
Ala242 (1)
Internal (1)
N Terminus (1)
aa1-50 (1)
aa127-155 (1)
aa215-264 (1)
aa8-19 (1)
aa80-130 (1)
aa9-36 (1)
p246 (1)
No (71)
Yes (2)
SNAI1 / SNAIL-1 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
SNAI1 / SNAIL-1 Antibody - IHC of SNAI 1 (A242) pAb in paraffin-embedded human lung carcinoma tissue.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (Ala242) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$394
SNAI1 / SNAIL-1 Antibody - Anti-SNAI1 / SNAIL-1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa215-264) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
SNAI1 / SNAIL-1 Antibody - Anti-SNAI1 / SNAIL antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa80-130) Antibody
Mouse, Dog, Horse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
SNAI1 / SNAIL-1 Antibody - Immunofluorescence of monoclonal antibody to SNAI1 on U-2 OS cell. [antibody concentration 10 ug/ml]
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SNAI1 / SNAIL-1 Mouse anti-Human Monoclonal (2G11) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$413
SNAI1 / SNAIL-1 Antibody - SNAI1 / SNAIL antibody ARP33314_P050-NP_005976-SNAI1 (snail homolog 1 (Drosophila)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$414
SNAI1 / SNAIL-1 Antibody - Formalin-fixed and paraffin-embedded human Spleen tissue reacted with SNAIL antibody (N-term D24) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa9-39) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$381
SNAI1 / SNAIL-1 Antibody - Western blot of Phospho-SNAI 1 (S246) antibody
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (190-270 aa) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
SNAI1 / SNAIL-1 Antibody - Immunohistochemistry of paraffin-embedded human colon carcinoma tissue.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
SNAI1 / SNAIL-1 Antibody - Western blot using SNAI1 monoclonal antibody against human SNAI1 (AA: 2-264) recombinant protein. (Expected MW is 31.3 kDa)
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SNAI1 / SNAIL-1 Mouse anti-Human Monoclonal (6D2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$426
SNAI1 / SNAIL-1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SNAI1 / SNAIL-1 Goat anti-Human Polyclonal (aa8-19) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
SNAI1 / SNAIL-1 Antibody - Western blot of SNAI1 / SNAIL-1 antibody.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa1-264) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$341; 500 µl/$481; 1 ml/$551
SNAI1 / SNAIL-1 Antibody - Western blot of SNAI 1 antibody
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (190-270 aa) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
SNAI1 / SNAIL-1 Antibody - Staining HT29 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (pSer246) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
SNAI1 / SNAIL-1 Antibody - Western blot of SNAI1 expression in HT29 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
SNAI1 / SNAIL-1 Antibody - Western blot of SNAI1 phosphorylation expression in HT29 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (pSer246) Antibody
Mouse, Human
ICC, IF, WB
Unconjugated
50 µg/$295; 100 µg/$347
SNAI1 / SNAIL-1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) HIER using 10 mM sodium citrate buffer pH 6.
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Fast Shipping
SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
IHC-P
Unconjugated
50 µg/$460
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
50 µl/$275; 100 µl/$312; 200 µl/$350
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa9-39) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$653
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (aa9-39) (PE) Antibody
Human
FLISA, IHC, WB
PE Conjugated
200 µl/$828
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
SNAI1 / SNAIL-1 Antibody - Immunohistochemistry of paraffin-embedded rat kidney using SNAI1 antibody at dilution of 1:100 (40x lens).
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
SNAI1 / SNAIL-1 Antibody - P-peptide - + Immunofluorescence analysis of HuvEc cells, using SNAI1 (Phospho-Ser246) antibody.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal (pSer246) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$347
SNAI1 / SNAIL-1 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using SNAI1 Polyclonal Antibody at dilution of 1:30.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$284; 120 µl/$343; 200 µl/$451
SNAI1 / SNAIL-1 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at dilution of 1:100.
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SNAI1 / SNAIL-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$348
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).