SMURF2

SMAD specific E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

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Products

Antibodies (31)

Proteins (5)

ELISA Kits (3)

Type

Competitive EIA (1)

Custom (1)

Over-Expression Lysate (2)

Primary (31)

Recombinant (3)

Sandwich (1)

Target

SMURF2 (39)

Reactivity

Human (32)

Mouse (12)

Rat (5)

Bat (1)

Guinea pig (1)

Horse (1)

Pig (1)

Rabbit (1)

Application

IHC (21)

IHC-P (6)

WB (27)

ELISA (18)

ICC (7)

IF (10)

Peptide-ELISA (1)

Host

rabbit (24)

mouse (7)

Product Group

IHCPlus (1)

Isotype

IgG (21)

IgG1 (6)

IgG1,k (1)

Clonality

monoclonal mc (7)

polyclonal pc (24)

Clone

1826CT865.51.28 (1)

OTI3E4 (2)

OTI5E4 (2)

OTI6E12 (2)

Format

96-Well Strip Plate (3)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (3)

Carrier-free (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Preservative Free (1)

Unconjugated (18)

Epitope

aa6-36 (7)

aa702-731 (7)

aa151-440 (6)

aa317-351 (1)

Publications

No (38)

Yes (1)

Sample Type

Cell Lysates (1)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

6His, N-terminus (1)

GST (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Yeast (1)

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Human SMURF2 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23464

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

88.2 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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SMURF2 Antibody (aa6-36) LS-C98005

(4.0) Rating

(1) Publication(s)

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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SMURF2 Antibody (aa151-440, clone OTI3E4) LS-C340056

Antibody:

SMURF2 Mouse anti-Human Monoclonal (aa151-440) (OTI3E4) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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SMURF2 Antibody (aa151-440, clone OTI3E4, Carrier-free) LS-C790994

Antibody:

SMURF2 Mouse anti-Human Monoclonal (aa151-440) (Carrier-free) (OTI3E4) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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SMURF2 Antibody (aa702-731) LS-C98006

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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SMURF2 Antibody (aa702-731) LS-C330164

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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SMURF2 Antibody (aa702-731, Biotin) LS-C217642

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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SMURF2 Antibody (aa702-731, FITC) LS-C217643

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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SMURF2 Antibody (aa702-731, APC) LS-C217641

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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SMURF2 Antibody (aa702-731, PE) LS-C217644

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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SMURF2 Antibody (aa702-731, Azide-free, HRP) LS-C217645

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa702-731) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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SMURF2 Antibody (aa6-36) LS-C328695

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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SMURF2 Antibody (aa6-36, Biotin) LS-C220711

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SMURF2 Antibody (aa6-36, FITC) LS-C220713

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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SMURF2 Antibody (aa6-36, APC) LS-C220708

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SMURF2 Antibody (aa6-36, Azide-free, HRP) LS-C220712

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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SMURF2 Antibody (aa6-36, PE) LS-C220714

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (aa6-36) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

SMURF2 Antibody LS-C806783

Antibody:

SMURF2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IHC-plus™ SMURF2 Antibody LS-B12061

(4.0) Rating

Antibody:

SMURF2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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SMURF2 Antibody (Preservative Free) LS-C815714

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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SMURF2 Antibody LS-C379608

Antibody:

SMURF2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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SMURF2 Antibody (HRP) LS-C379609

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

SMURF2 Antibody (Biotin) LS-C379613

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

SMURF2 Antibody (FITC) LS-C379616

Antibody:

SMURF2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SMURF2 Antibody (clone 1826CT865.51.28) LS-C757683

Antibody:

SMURF2 Mouse anti-Human Monoclonal (1826CT865.51.28) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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