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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMN1

survival of motor neuron 1, telomeric

SMN1 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.

Gene Name: survival of motor neuron 1, telomeric
Synonyms: SMN1, BCD541, Component of gems 1, Gemin-1, SMA2, SMA4, SMA@, SMA1, SMNC, SMNT, T-BCD541, SMN, Survival motor neuron protein, Gemin 1, GEMIN1, SMA, SMA3
Target Sequences: NM_000344 NP_000335.1

Filtered by: None
Target
SMN1 (56)
Reactivity
Human (56)
Mouse (20)
Rat (4)
Chimpanzee (7)
Dog (5)
Gibbon (6)
Monkey (9)
Non-Human Primate (2)
Orangutan (6)
Pig (12)
Rabbit (1)
Xenopus (2)
Application
IHC (16)
IHC-P (9)
WB (52)
Flo (2)
ELISA (18)
ICC (5)
IF (5)
IP (7)
Host
rabbit (45)
mouse (11)
Isotype
IgG (23)
IgG1 (9)
IgG1,k (1)
Clonality
monoclonal mc (11)
polyclonal pc (45)
Clone
2B1 (2)
2F1 (2)
5H1 (2)
7B10 (1)
SCB3 (1)
Format
AP Conjugated (1)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (6)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (27)
Epitope
aa16-251 (8)
aa2-294 (8)
aa262-288 (8)
C-Terminus (4)
aa45-94 (4)
aa22-52 (1)
aa244-294 (1)
aa50-100 (1)
Publications
No (56)
Showing 1-25 of 56 results

IHC-plus™ SMN1 Antibody (aa45-94) LS-B5701
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-SMN1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMN1 Antibody (aa45-94, HRP) LS-C439890
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Dog, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-SMN1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMN1 Antibody (aa45-94, Biotin) LS-C439888
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Dog, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-SMN1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMN1 Antibody (clone 5H1) LS-C169372
Mouse Monoclonal [clone 5H1] (IgG1) to Human SMN1
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100µl  $365.00
IHC of paraffin-embedded breast cancer tissues (left) and testis tissues (right) using SMN1 mouse monoclonal antibody with DAB staining.
IHC of paraffin-embedded stomach cancer tissues (left) and brain tumor (right) using SMN1 mouse monoclonal antibody with DAB staining.

SMN1 Antibody LS-C91862
Mouse Monoclonal (IgG1) to Human SMN1
Xenopus, Mouse, Human
ELISA, IF, IP, WB
Unconjugated
50µl  $465.00

SMN1 Antibody (clone 2B1) LS-C82216
Mouse Monoclonal [clone 2B1] (IgG1) to Human SMN1
Xenopus, Mouse, Human
ELISA, ICC, IF, IP, WB
Unconjugated
50µl 1mg/ml  $450.00
Immunocytochemistry of SMN / SMA antibody.

SMN1 Antibody (aa262-288) LS-C159042
Rabbit Polyclonal to Human SMN1
Human
WB
Unconjugated
400µl  $325.00
SMN1 Antibody western blot of 293 cell line lysates (35 ug/lane). The SMN1 antibody detected the SMN1 protein (arrow).

SMN1 Antibody (C-Terminus) LS-C169737
Rabbit Polyclonal to Human SMN1
Pig, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMN1 Antibody (C-Terminus, HRP) LS-C470829
Rabbit Polyclonal to Human SMN1
Pig, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMN1 Antibody (clone SCB3) LS-C144551
Mouse Monoclonal [clone SCB3] (IgG1,k) to Human SMN1
Human
IHC, IP, WB
Unconjugated
25µg  $365.00

SMN1 Antibody (clone 5H1) LS-C758942
Mouse Monoclonal [clone 5H1] (IgG1) to Human SMN1
Mouse, Human, Non-Human Primate
ICC, IF, IHC, WB
Unconjugated
100µl  $445.00
SMN Antibody in Immunohistochemistry (IHC)
SMN Antibody in Immunohistochemistry (IHC)

SMN1 Antibody (clone 2F1) LS-C169370
Mouse Monoclonal [clone 2F1] (IgG1) to Human SMN1
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µl  $365.00
IHC of paraffin-embedded testis tissues (left) and lung cancer tissues (right) using SMN1 mouse monoclonal antibody with DAB staining.
Western blot using SMN1 mouse monoclonal antibody against HepG2 (1), HeLa (2), K562 (3), Jurkat (4), SKBR-3 (5), A431 (6) and Cos7 (7) cell lysate.

SMN1 Antibody LS-C500759
Rabbit Polyclonal (IgG) to Human SMN1
Human
ELISA, IF, IHC, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human testis tissue using SMN1 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using SMN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

IHC-plus™ SMN1 Antibody (aa50-100) LS-B15088
Rabbit Polyclonal (IgG) to Human SMN1
Human
IHC, IHC-P, IP
Unconjugated
50µl 1mg/ml  $425.00
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

SMN1 Antibody (clone 2F1) LS-C758666
Mouse Monoclonal [clone 2F1] (IgG1) to Human SMN1
Human, Non-Human Primate
Flo, IHC, WB
Unconjugated
100µl  $405.00
SMN Antibody in Immunohistochemistry (IHC)
SMN Antibody in Western Blot (WB)

SMN1 Antibody LS-C756665
Mouse Monoclonal (IgG1) to Human SMN1
Human
ICC, IHC-P, WB
Unconjugated
100µg  $325.00
IHC analysis of SMN1/2 using anti-SMN1/2 antibody. SMN1/2 was detected in paraffin-embedded section of human mammary cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml mouse anti-SMN1/2 antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
IHC analysis of SMN1/2 using anti-SMN1/2 antibody. SMN1/2 was detected in paraffin-embedded section of human mammary cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml mouse anti-SMN1/2 antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.

SMN1 Antibody (aa22-52) LS-C357585
Rabbit Polyclonal to Human SMN1
Rabbit, Mouse, Dog, Rat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg 200µl 0.5mg/ml  $325.00
SMN1/2 antibody IHC-paraffin: Mouse Brain Tissue.
SMN1/2 antibody IHC-paraffin: Rat Brain Tissue.

SMN1 Antibody (aa16-251) LS-C373161
Rabbit Polyclonal to Human SMN1
Mouse, Human
ICC, IP, WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00
Western blot of SMN1 antibody.
Western Blot; Sample: Lane1: Human Serum; Lane2: Human Hela Cells; Lane3: Human HepG2 Cells; Lane4: Human 293T Cells; Lane5: Mouse Testis Tissue.

SMN1 Antibody (aa2-294) LS-C374392
Rabbit Polyclonal to Human SMN1
Pig, Human
ICC, IP, WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00
Western blot of SMN1 antibody.
Western Blot; Sample: Lane1: Human Hela Cells; Lane2: Human 293T Cells; Lane3: Human hepG2 Cells.

SMN1 Antibody LS-C770739
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

SMN1 Antibody LS-C770740
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

SMN1 Antibody LS-C770741
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

SMN1 Antibody LS-C412283
Rabbit Polyclonal to Human SMN1
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $385.00

SMN1 Antibody LS-C752171
Mouse Monoclonal (IgG1) to Human SMN1
Human
ELISA, WB
Unconjugated
100µg  $355.00

SMN1 Antibody (aa262-288) LS-C325208
Rabbit Polyclonal (IgG) to Human SMN1
Human
ELISA, WB
Unconjugated
200µl  $590.00
Showing 1-25 of 56 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).