Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

SMN1

survival of motor neuron 1, telomeric

SMN1 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.

Gene Name: survival of motor neuron 1, telomeric
Synonyms: SMN1, BCD541, Component of gems 1, Gemin-1, SMA2, SMA4, SMA@, SMA1, SMNC, SMNT, T-BCD541, SMN, Survival motor neuron protein, Gemin 1, GEMIN1, SMA, SMA3
Target Sequences: NM_000344 NP_000335.1

Viewing 1-25 of 57 items
SMN1 Antibody - Anti-SMN1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Cancer
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Dog, Human, Monkey
IHC-P, WB
Unconjugated
100µl   $485.00
SMN1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Rabbit Polyclonal (IgG) to Human SMN1
Human
IHC-P, IP
Unconjugated
50µl   1mg/ml   $425.00
SMN1 Antibody - IHC of paraffin-embedded breast cancer tissues (left) and testis tissues (right) using SMN1 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 5H1] (IgG1) to Human SMN1
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100µl   $365.00
Select
Mouse Monoclonal (IgG1) to Human SMN1
Xenopus, Mouse, Human
ELISA, IF, IP, WB
Unconjugated
50µl   $465.00
SMN1 Antibody - Immunocytochemistry of SMN / SMA antibody.
Select
Mouse Monoclonal [clone 2B1] (IgG1) to Human SMN1
Xenopus, Mouse, Human
ELISA, ICC, IF, IP, WB
Unconjugated
50µl   1mg/ml   $450.00
SMN1 Antibody - SMN1 Antibody western blot of 293 cell line lysates (35 ug/lane). The SMN1 antibody detected the SMN1 protein (arrow).
Select
Rabbit Polyclonal to Human SMN1
Human
WB
Unconjugated
400µl   $325.00
SMN1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SMN1
Pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
SMN1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human SMN1
Pig, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
Select
Mouse Monoclonal [clone SCB3] (IgG1,k) to Human SMN1
Human
IHC, IP, WB
Unconjugated
25µg   $365.00
SMN1 Antibody - SMN Antibody in Immunohistochemistry (IHC)
Select
Mouse Monoclonal [clone 5H1] (IgG1) to Human SMN1
Mouse, Human, Non-Human Primate
ICC, IF, IHC, WB
Unconjugated
100µl   $445.00
SMN1 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded breast cancer tissues (left) and testis tissues (right) with DAB staining using SMN1 Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human SMN1
Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   $345.00
SMN1 Antibody
Select
Mouse Monoclonal [clone 2B1] (IgG1) to Human SMN1
Xenopus laevis, Mouse, Human
ELISA, Flo, ICC, IF, IHC-P, IP, WB
Unconjugated
0.1ml   1mg/ml   $415.00
SMN1 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded testis tissues (left) and Lung Cancer Tissues (right) with DAB staining using SMN1 Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human SMN1
Human, Monkey
ELISA, Flo, IHC, WB
Unconjugated
100µl   $345.00
SMN1 Antibody - IHC of paraffin-embedded testis tissues (left) and lung cancer tissues (right) using SMN1 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 2F1] (IgG1) to Human SMN1
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µl   $365.00
SMN1 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using SMN1 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human SMN1
Human
ELISA, IF, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
SMN1 Antibody - SMN Antibody in Immunohistochemistry (IHC)
Select
Mouse Monoclonal [clone 2F1] (IgG1) to Human SMN1
Human, Non-Human Primate
Flo, IHC, WB
Unconjugated
100µl   $405.00
SMN1 Antibody - IHC analysis of SMN1/2 using anti-SMN1/2 antibody. SMN1/2 was detected in paraffin-embedded section of human mammary cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml mouse anti-SMN1/2 antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Select
Mouse Monoclonal (IgG1) to Human SMN1
Human
ICC, IHC-P, WB
Unconjugated
100µg   $325.00
SMN1 Antibody - SMN1/2 antibody IHC-paraffin: Mouse Brain Tissue.
Select
Rabbit Polyclonal to Human SMN1
Rabbit, Mouse, Dog, Rat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
SMN1 Antibody - Western blot of SMN1 antibody.
Select
Rabbit Polyclonal to Human SMN1
Pig, Human
ICC, IP, WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $530.00
SMN1 Antibody - Western blot of SMN1 antibody.
Select
Rabbit Polyclonal to Human SMN1
Mouse, Human
ICC, IP, WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $530.00
Select
Rabbit Polyclonal to Human SMN1
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human SMN1
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Mouse Monoclonal (IgG1) to Human SMN1
Human
ELISA, WB
Unconjugated
100µg   $355.00

Viewing 1-25 of 57 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).