SMMHC / MYH11

Myosin, Heavy Chain 11, Smooth Muscle

SMMHC / MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SMMHC / MYH11 (4)

Publications

No (4)

Tag

His (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

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SMMHC / MYH11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120250

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

227.9 kDa

Price:

100 µg/$710

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Human SMMHC / MYH11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77534

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

227.9 kDa

Price:

20 µg/$215

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Rat SMMHC / MYH11 Protein (Recombinant His) (aa211-482) - LS-G15288

Source:

E. coli

Tag:

His

Molecular Weight:

32.6 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human SMMHC / MYH11 Protein (Recombinant His-T7, N-terminus) (Ala162-Gln315) - LS-G133365

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

19.2kDa

Price:

10 µg/$269; 50 µg/$370; 200 µg/$737; 100 µg/$590; 1 mg/$1,779; 500 µg/$1,345; 5 mg/$2,736; 2 mg/$1,959

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