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SMG7

SMG7 nonsense mediated mRNA decay factor

SMG7 is a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name:	SMG7 nonsense mediated mRNA decay factor
Synonyms:	SMG7, EST1-like protein C, EST1C, Ever shorter telomeres 1C, HSMG-7, SGA56M, SMG-7, C1orf16, KIAA0250, Protein SMG7, SMG-7 homolog
Target Sequences:	NM_173156 NP_775179.1 Q92540

Human SMG7 (Cell-Based ELISA) ELISA Kit - LS-F3269

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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