SMG6

SMG6 nonsense mediated mRNA decay factor

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)4GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.

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Products

Proteins (2)

Type

Over-Expression Lysate (2)

Target

SMG6 (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human SMG6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82823

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.3 kDa

Price:

20 µg/$215

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SMG6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112387

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

160.3 kDa

Price:

100 µg/$710

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