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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMG6

SMG6 nonsense mediated mRNA decay factor

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)4GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.

Gene Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: SMG6, C17orf31, EST1-like protein A, Ever shorter telomeres 1A, KIAA0732, Smg-6 homolog, SMG-6, Telomerase subunit EST1A, EST1A, HSMG5/7a
Target Sequences: NM_017575 NP_060045.4 Q86US8

Filtered by: None
Target
SMG6 (5)
Reactivity
Human (5)
Rat (1)
Application
IHC (2)
IHC-P (2)
WB (1)
ELISA (4)
Host
rabbit (5)
Isotype
IgG (5)
Clonality
polyclonal pc (5)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (2)
Publications
No (5)
Showing 1-5 of 5 results

SMG6 Antibody IHC-plus™ LS-B15630
Rabbit Polyclonal (IgG) to Human SMG6
Rat, Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

SMG6 Antibody LS-C398998
Rabbit Polyclonal (IgG) to Human SMG6
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human gastric cancer using antibody at dilution of 1:100.

SMG6 Antibody (HRP) LS-C398986
Rabbit Polyclonal (IgG) to Human SMG6
Human
ELISA
HRP Conjugated
50µg  $285.00; 100µg  $385.00

SMG6 Antibody (Biotin) LS-C398987
Rabbit Polyclonal (IgG) to Human SMG6
Human
ELISA
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

SMG6 Antibody (FITC) LS-C398977
Rabbit Polyclonal (IgG) to Human SMG6
Human
ELISA
FITC Conjugated
50µg  $285.00; 100µg  $385.00
Showing 1-5 of 5 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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