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Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the de novo methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells.
Gene Name: | Structural Maintenance Of Chromosomes Flexible Hinge Domain Containing 1 |
Synonyms: | SMCHD1, KIAA0650 |
Target Sequences: | AL080138 CAB45732.1 A6NHR9 |
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