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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMC3 / HCAP

structural maintenance of chromosomes 3

Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.

Gene Name: structural maintenance of chromosomes 3
Synonyms: SMC3, Bamacan, CDLS3, CSPG6, HCAP, SMC-3, BAM, BMH, SMC protein 3, SMC3L1
Target Sequences: NM_005445 NP_005436.1 Q9UQE7

Filtered by: None
Target
SMC3 / HCAP (38)
Reactivity
Human (37)
Mouse (18)
Rat (13)
Bat (9)
Bovine (10)
Chicken (5)
Chimpanzee (6)
Dog (9)
Gibbon (6)
Guinea pig (9)
Hamster (1)
Horse (9)
Monkey (8)
Orangutan (6)
Pig (9)
Rabbit (9)
Sheep (1)
Xenopus (8)
Zebrafish (8)
Application
IHC (9)
IHC-P (7)
WB (35)
ELISA (9)
ICC (1)
IP (4)
Host
rabbit (35)
mouse (2)
rat (1)
Isotype
IgG (19)
IgG1 (1)
IgG2a (1)
IgG2b,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (35)
Clone
2F11 (1)
KT75 (1)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (19)
Epitope
aa402-430 (8)
aa994-1181 (8)
aa1051-1100 (4)
aa215-264 (4)
pSer1083 (4)
aa1175-C-term (2)
aa1178-1216 (1)
aa325-375 (1)
pSer383 (1)
Publications
No (38)
Showing 1-25 of 38 results

IHC-plus™ SMC3 / HCAP Antibody (aa1051-1100) LS-B5803
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Xenopus, Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-SMC3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 8%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMC3 / HCAP Antibody (aa1051-1100, HRP) LS-C450161
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Xenopus, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-SMC3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 8%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMC3 / HCAP Antibody (aa1051-1100, Biotin) LS-C450159
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Xenopus, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-SMC3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 8%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMC3 / HCAP Antibody (aa1051-1100, FITC) LS-C450160
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Xenopus, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-SMC3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 8%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMC3 / HCAP Antibody (aa1175-C-term) LS-C287002
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Mouse, Human
IHC, IP, WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human SMC3 by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-SMC3 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Detection of mouse SMC3 by immunohistochemistry. Sample: FFPE section of mouse plasmacytoma. Antibody: Affinity purified rabbit anti-SMC3 used at 1:1,000 (1µg/ml). Detection: DAB

SMC3 / HCAP Antibody (aa1178-1216) LS-C407958
Rabbit Polyclonal to Human SMC3 / HCAP
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P, WB
Unconjugated
100µg  $355.00
SMC3 antibody IHC-paraffin. IHC(P): Mouse Intestine Tissue.
SMC3 antibody IHC-paraffin. IHC(P): Rat Kidney Tissue.

SMC3 / HCAP Antibody LS-C490418
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg  $435.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

SMC3 / HCAP Antibody (aa994-1181) LS-C296522
Rabbit Polyclonal to Human SMC3 / HCAP
Human
ICC, IP, WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $495.00
Western blot of recombinant SMC3 / HCAP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western Blot; Sample: Lane1: Human HepG2 Cells; Lane2: Human Hela Cells; Lane3: Human Jurkat Cells.

SMC3 / HCAP Antibody LS-C756654
Mouse Monoclonal (IgG1) to Human SMC3 / HCAP
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100µg  $355.00
IHC analysis of SMC3 using anti-SMC3 antibody. SMC3 was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml mouse anti-SMC3 antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
IHC analysis of SMC3 using anti-SMC3 antibody. SMC3 was detected in paraffin-embedded section of human lung cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml mouse anti-SMC3 antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.

SMC3 / HCAP Antibody (clone 2F11) LS-C139467
Mouse Monoclonal [clone 2F11] (IgG2b,k) to Human SMC3 / HCAP
Human
ELISA, WB
Unconjugated
100µg  $355.00
Western blot of SMC3 expression in transfected 293T cell line by CSPG6 monoclonal antibody (M02), clone 2F11.
Detection limit for recombinant GST tagged CSPG6 is approximately 0.3 ng/ml as a capture antibody.

SMC3 / HCAP Antibody (aa402-430) LS-C330163
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
Unconjugated
200µl  $590.00

SMC3 / HCAP Antibody (aa402-430, Biotin) LS-C269687
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

SMC3 / HCAP Antibody (aa402-430, FITC) LS-C269688
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

SMC3 / HCAP Antibody (aa402-430, AP) LS-C269686
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
AP Conjugated
200µl  $740.00

SMC3 / HCAP Antibody (aa402-430, APC) LS-C269689
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
APC Conjugated
200µl  $740.00

SMC3 / HCAP Antibody (aa402-430, Azide-free, HRP) LS-C269690
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

SMC3 / HCAP Antibody (aa402-430, PE) LS-C269691
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
PE Conjugated
200µl  $740.00

SMC3 / HCAP Antibody LS-C753071
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
ELISA, WB
Unconjugated
100µg  $355.00

SMC3 / HCAP Antibody (phospho-Ser1083) LS-C762158
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Human
IP, WB
Unconjugated
100µg 100µl 1mg/ml  $415.00
Detection of human Phospho SMC3 (S1083) by western blot (WB). Samples: Whole cell lysate (50 µg) from HeLa cells treated with 100 µM etoposide and/or 100 µM phosphatase for 4 hours (+) or mock treated (-) cells. Antibodies: Affinity purified rabbit anti-Phospho SMC3 (S1083) antibodyused for WB at 1 µg/ml (upper panel); to detect total SMC3, rabbit anti-SMC3 was used for WB at 0.1 µg/ml (lower panel). Detection: Chemiluminescence with an exposure time of 3 minutes (upper panel) or 10 seconds (lower panel).

SMC3 / HCAP Antibody (clone KT75) LS-C193507
Rat Monoclonal [clone KT75] (IgG2a) to Mouse SMC3 / HCAP
Mouse
WB
Unconjugated
100µg  $355.00

SMC3 / HCAP Antibody (phospho-Ser1083) LS-C286341
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Mouse, Human
IHC
Unconjugated
100µl  $425.00
Detection of Human Phospho-SMC3 (S1083) by Immunohistochemistry. Samples: FFPE serial sections of human colon adenocarcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for Phospho-SMC3. Antibody: Affinity purified rabbit anti-Phospho-SMC3 (S1083) used at a dilution of 1:250. Detection: DAB staining using anti-rabbit IHC Antibody at a dilution of 1:100.
Detection of Mouse Phospho-SMC3 (S1083) by Immunohistochemistry. Samples: FFPE serial sections of mouse squamous cell carcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for Phospho-SMC3. Antibody: Affinity purified rabbit anti-Phospho-SMC3 (S1083) used at a dilution of 1:250. Detection: DAB staining using anti-rabbit IHC Antibody at a dilution of 1:100.

SMC3 / HCAP Antibody (aa1175-C-term) LS-C286329
Rabbit Polyclonal (IgG) to Human SMC3 / HCAP
Mouse, Human
IHC
Unconjugated
100µl  $415.00
Detection of Human SMC3 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma Antibody: Affinity purified rabbit anti-SMC3 used at a dilution of 1:250. Detection: DAB.
Detection of Mouse SMC3 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-SMC3 used at a dilution of 1:250. Detection: DAB.

SMC3 / HCAP Antibody (aa402-430) LS-C161312
Rabbit Polyclonal to Human SMC3 / HCAP
Human
WB
Unconjugated
400µl  $325.00
SMC3 Antibody western blot of CEM cell line lysates (35 ug/lane). The SMC3 antibody detected the SMC3 protein (arrow).

SMC3 / HCAP Antibody (phospho-Ser1083) LS-C412248
Rabbit Polyclonal to Human SMC3 / HCAP
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $385.00
Western blot of p-SMC3 (S1083) antibody at 1:500 dilution. Lane 1: A549 whole cell lysate. Lane 2: sp2/0 whole cell lysate. Lane 3: PC12 whole cell lysate.

SMC3 / HCAP Antibody (phospho-Ser1083) LS-C354391
Rabbit Polyclonal to Human SMC3 / HCAP
Mouse, Bovine, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot analysis of HCAP (pS1083) expression in A549 (A); NS-1 (B); PC12 (C) whole cell lysates.
Showing 1-25 of 38 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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