SMC1A / SMC1

structural maintenance of chromosomes 1A

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SMC1A / SMC1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human SMC1A / SMC1 Protein (Recombinant GST, N-terminus) (aa366-465) - LS-G60674

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMC1A / SMC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77030

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

143.1 kDa

Price:

20 µg/$215

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SMC1A / SMC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100785

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

143.1 kDa

Price:

100 µg/$710

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