SMARCE1 / BAF57

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SMARCE1 / BAF57 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SMARCE1 / BAF57 Protein (Recombinant GST, N-terminus) (aa75-142) - LS-G60147

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMARCE1 / BAF57 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83690

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

20 µg/$150

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Human SMARCE1 / BAF57 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69033

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

20 µg/$1,107

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Human SMARCE1 / BAF57 Protein (Recombinant GST) (Full Length) - LS-G30464

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.1 kDa

Price:

10 µg/$479; 25 µg/$670

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SMARCE1 / BAF57 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99957

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.5 kDa

Price:

100 µg/$494

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