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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SMARCC2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Gene Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: SMARCC2, BRG1-associated factor 170, CRACC2, SWI3-like protein, BAF170, Rsc8
Target Sequences: NM_003075 NP_003066.2 Q8TAQ2

Filtered By: None
Target
SMARCC2 (15)
Reactivity
Human (15)
Mouse (9)
Rat (3)
Bat (4)
Bovine (6)
Chimpanzee (3)
Dog (1)
Gibbon (3)
Horse (6)
Monkey (4)
Pig (6)
Rabbit (5)
Application
IHC (5)
IHC-P (3)
WB (14)
ChrIP (1)
ELISA (3)
ICC (1)
IF (5)
IP (2)
Peptide-ELISA (1)
Host
rabbit (14)
mouse (1)
Isotype
IgG (8)
IgG1 (1)
Clonality
monoclonal mc (1)
polyclonal pc (14)
Clone
AB02/2E2 (1)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (12)
Epitope
aa254-303 (4)
C-Terminus (2)
330-410 aa, Internal (1)
Internal (1)
Met388 (1)
aa300-650 (1)
aa361-410 (1)
aa575-625 (1)
Publications
No (15)
Showing 1-15 of 15 results

SMARCC2 Antibody (C-Terminus) LS-C287869
Rabbit Polyclonal (IgG) to Human SMARCC2
Mouse, Human
IHC IHC-P IP WB
Unconjugated
100µl 0.2mg/ml  $395.00
Detection of Human SMARCC2/BAF170 by Immunohistochemistry. Sample: FFPE section of human skin basal cell carcinoma. Antibody: Affinity purified rabbit anti-SMARCC2/BAF170 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
Detection of Human SMARCC2/BAF170 by Immunohistochemistry. Sample: FFPE section of human skin basal cell carcinoma. Antibody: Affinity purified rabbit anti-SMARCC2/BAF170 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

SMARCC2 Antibody LS-C660489
Rabbit Polyclonal (IgG) to Human SMARCC2
Human
ELISA IF IHC WB
Unconjugated
100µg  $435.00

SMARCC2 Antibody (aa300-650) LS-C378925
Rabbit Polyclonal (IgG) to Human SMARCC2
Mouse, Human
ChrIP ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human rectal cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human epityphlon using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human rectal cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human epityphlon using antibody at 1:100 dilution.

SMARCC2 Antibody (Internal) LS-C354078
Rabbit Polyclonal to Human SMARCC2
Mouse, Rat, Human
ICC IF WB
Unconjugated
100µl 1mg/ml  $245.00
Immunofluorescent analysis of BAF170 staining in Raji cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of BAF170 expression in Raji (A); MCF7 (B); mouse liver (C); rat liver (D) whole cell lysates.
Immunofluorescent analysis of BAF170 staining in Raji cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of BAF170 expression in Raji (A); MCF7 (B); mouse liver (C); rat liver (D) whole cell lysates.

SMARCC2 Antibody (C-Terminus) LS-C286461
Rabbit Polyclonal (IgG) to Human SMARCC2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human SMARCC2/BAF170 by Immunohistochemistry. Sample: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-SMARCC2/BAF170 used at a dilution of 1:500.
Detection of Mouse SMARCC2/BAF170 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-SMARCC2/BAF170 used at a dilution of 1:500.
Detection of Human SMARCC2/BAF170 by Immunohistochemistry. Sample: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-SMARCC2/BAF170 used at a dilution of 1:500.
Detection of Mouse SMARCC2/BAF170 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-SMARCC2/BAF170 used at a dilution of 1:500.

SMARCC2 Antibody (330-410 aa, Internal) LS-C382226
Rabbit Polyclonal (IgG) to Human SMARCC2
Mouse, Human
ELISA IF WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of BAF170 antibody
Western blot of BAF170 antibody
Western blot of BAF170 antibody
Western blot of BAF170 antibody

SMARCC2 Antibody LS-C331791
Rabbit Polyclonal (IgG) to Human SMARCC2
Mouse, Rat, Human
IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded rat kidney tissue.
Immunohistochemistry of paraffin-embedded human prostate cancer tissue.
Immunohistochemistry of paraffin-embedded rat kidney tissue.
Immunohistochemistry of paraffin-embedded human prostate cancer tissue.

SMARCC2 Antibody (Met388) LS-C176824
Rabbit Polyclonal to Human SMARCC2
Mouse, Human
IF WB
Unconjugated
100µl  $345.00
Western blot of BAF170 (M388) pAb in extracts from HUVEC cells.
Western blot of BAF170 (M388) pAb in extracts from HUVEC cells.

SMARCC2 Antibody (aa575-625) LS-C287878
Rabbit Polyclonal (IgG) to Human SMARCC2
Mouse, Bovine, Pig, Horse, Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

SMARCC2 Antibody (aa361-410) LS-C119160
Rabbit Polyclonal (IgG) to Human SMARCC2
Mouse, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HUVEC and COLO205 cells, using SMRC2 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC and COLO205 cells, using SMRC2 Antibody. The lane on the right is blocked with the synthesized peptide.

SMARCC2 Antibody (clone AB02/2E2) LS-C746365
Mouse Monoclonal [clone AB02/2E2] (IgG1) to Human SMARCC2
Human
WB
Unconjugated
100µl  $425.00

SMARCC2 Antibody (aa254-303) LS-C206181
Rabbit Polyclonal to Human SMARCC2
Rabbit, Bovine, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMARCC2 Antibody (aa254-303, HRP) LS-C479687
Rabbit Polyclonal to Human SMARCC2
Rabbit, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMARCC2 Antibody (aa254-303, Biotin) LS-C479685
Rabbit Polyclonal to Human SMARCC2
Rabbit, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SMARCC2 Antibody (aa254-303, FITC) LS-C479686
Rabbit Polyclonal to Human SMARCC2
Rabbit, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SMARCC2 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-15 of 15 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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