SMARCA5 / SNF2H

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.

☰ Filters

Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SMARCA5 / SNF2H (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Select

Human SMARCA5 / SNF2H Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88974

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

121.8 kDa

Price:

20 µg/$150

Select

Human SMARCA5 / SNF2H Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71141

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

121.8 kDa

Price:

20 µg/$1,107

Select

Human SMARCA5 / SNF2H Protein (Recombinant GST, N-terminus) (aa59-147) - LS-G60733

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

SMARCA5 / SNF2H Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100079

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

121.8 kDa

Price:

100 µg/$494

Viewing 1-4 of 4 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.