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SMARCA3 / HLTF
helicase-like transcription factor
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
| Gene Name: | helicase-like transcription factor |
| Synonyms: | HLTF, HIP116, HIP116A, HLTF1, SMARCA3, Sucrose nonfermenting-like 3, ZBU1, RING finger protein 80, SNF2L3, RNF80, SNF2-like 3 |
| Target Sequences: | NM_003071 NP_003062.2 Q14527 |
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