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SMAD6

SMAD family member 6

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Gene Name: SMAD family member 6
Synonyms: SMAD6, AOVD2, HSMAD6, HsT17432, SMAD 6, MADH7, Mothers against DPP homolog 6, SMAD family member 6, MAD homolog 6, MADH6
Target Sequences: NM_005585 NP_005576.3 O43541

☰ Filters
Products
Antibodies (73)
Primary (73)
SMAD6 (73)
Human (51)
Mouse (29)
Rat (19)
Bovine (9)
Chimpanzee (12)
Dog (6)
Gibbon (12)
Guinea pig (3)
Horse (3)
Monkey (7)
Pig (10)
Rabbit (3)
IHC (17)
IHC-P (11)
WB (71)
Flo (7)
ELISA (20)
ICC (1)
IF (1)
Peptide-ELISA (2)
rabbit (66)
mouse (7)
Product Group
IHCPlus (6)
IgG (25)
IgG1 (3)
IgG2a,k (1)
IgG2b,k (3)
monoclonal mc (7)
polyclonal pc (66)
1G2 (1)
2A6 (1)
4C8 (1)
4F3 (1)
5H3 (2)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (9)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (9)
HRP Conjugated (9)
PE Conjugated (5)
Unconjugated (30)
aa116-364 (8)
aa171-441 (8)
aa261-495 (8)
aa357-386 (7)
aa358-386 (7)
aa11-60 (4)
aa136-185 (4)
aa137-182 (4)
aa398-447 (4)
Internal (2)
C-Terminus (1)
aa323-372 (1)
aa85-99 (1)
No (73)
SMAD6 Antibody - Anti-SMAD6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SMAD6 Mouse anti-Human Monoclonal (4F3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
SMAD6 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SMAD6 Rabbit anti-Human Polyclonal (aa323-372) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SMAD6 Antibody - Anti-SMAD6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SMAD6 Mouse anti-Human Monoclonal (1G2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
SMAD6 Antibody - Anti-SMAD6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SMAD6 Mouse anti-Human Monoclonal (4C8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
SMAD6 Antibody - Anti-SMAD6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SMAD6 Rabbit anti-Human Polyclonal (aa85-99) Antibody
Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
SMAD6 Antibody - SMAD6 antibody ARP32690_T100-NP_005576-SMAD6 (SMAD family member 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD6 Rabbit anti-Human Polyclonal (aa137-182) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
SMAD6 Antibody - SMAD6 antibody ARP32690_T100-NP_005576-SMAD6 (SMAD family member 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD6 Rabbit anti-Human Polyclonal (aa137-182) (HRP) Antibody
Mouse, Dog, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
SMAD6 Antibody - SMAD6 antibody ARP32690_T100-NP_005576-SMAD6 (SMAD family member 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD6 Rabbit anti-Human Polyclonal (aa137-182) (Biotin) Antibody
Mouse, Dog, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
SMAD6 Antibody - SMAD6 antibody ARP32690_T100-NP_005576-SMAD6 (SMAD family member 6) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SMAD6 Rabbit anti-Human Polyclonal (aa137-182) (FITC) Antibody
Mouse, Dog, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
SMAD6 Antibody - Anti-SMAD6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SMAD6 Mouse anti-Human Monoclonal (2A6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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SMAD6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
100 µg/$649
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SMAD6 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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SMAD6 Rabbit anti-Human Polyclonal (aa358-386) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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SMAD6 Rabbit anti-Human Polyclonal (aa358-386) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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SMAD6 Rabbit anti-Human Polyclonal (aa358-386) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
SMAD6 Rabbit anti-Human Polyclonal (aa358-386) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
SMAD6 Rabbit anti-Human Polyclonal (aa358-386) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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SMAD6 Rabbit anti-Human Polyclonal (aa358-386) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
SMAD6 Antibody - Immunofluorescence staining of SMAD6 in A549 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human SMAD6 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus and Cytoplasm.
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SMAD6 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
SMAD6 Antibody - Immunohistochemical analysis of SMAD6 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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SMAD6 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
SMAD6 Antibody - 1:100 staining human lung tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SMAD6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SMAD6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
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SMAD6 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
SMAD6 Antibody - Immunohistochemistry of paraffin-embedded rat brain using SMAD6 antibody at dilution of 1:100 (40x lens).
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SMAD6 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
SMAD6 Antibody - Western blot using SMAD6 mouse monoclonal antibody against A431 (1), A431 (2), HeLa (3) and Jurkat (4) cell lysate.
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SMAD6 Mouse anti-Human Monoclonal (5H3) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
Viewing 1-25 of 73 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).