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SMAD5

SMAD family member 5

SMAD5 is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.

Gene Name: SMAD family member 5
Synonyms: SMAD5, JV5-1, MADH5, SMAD 5, MAD homolog 5, Mothers against DPP homolog 5, SMA- and MAD-related protein 5, SMAD family member 5, DWFC, HSmad5
Target Sequences: NM_005903 NP_005894.3 Q99717

Publications (1)

1
Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD. The Journal of biological chemistry. 2008 283:3877-88. (WB, IP) [PubMed:18042551]

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).