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SMAD5 is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.
Gene Name: | SMAD family member 5 |
Synonyms: | SMAD5, JV5-1, MADH5, SMAD 5, MAD homolog 5, Mothers against DPP homolog 5, SMA- and MAD-related protein 5, SMAD family member 5, DWFC, HSmad5 |
Target Sequences: | NM_005903 NP_005894.3 Q99717 |
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