SMAD2

SMAD family member 2

SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

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Products

Proteins (17)

Type

Over-Expression Lysate (7)

Recombinant (10)

Target

SMAD2 (17)

Publications

No (17)

Tag

6His, N-terminus (1)

6His-DDK (Flag), C-terminus (1)

6His-SUMO, N-terminus (1)

GST, N-terminus (1)

His (3)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (8)

Species

Human (12)

Mouse (2)

Source

293T Cells (3)

Baculovirus (1)

E. coli (6)

HEK 293 Cells (6)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

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SMAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125577

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

100 µg/$494

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Human SMAD2 Protein (Recombinant GST, N-terminus) (aa181-280) - LS-G59159

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMAD2 Protein (Recombinant 6His-DDK (Flag), C-terminus) (Ser2-Ser467) - LS-G139116

Source:

E. coli

Tag:

6His-DDK (Flag), C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

54.6 kDa

Price:

10 µg/$277; 50 µg/$389

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Human SMAD2 Protein (Recombinant 6His-SUMO, N-terminus) (aa2-467) - LS-G56710

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SMAD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69771

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.1 kDa

Price:

20 µg/$1,107

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Human SMAD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69773

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.1 kDa

Price:

20 µg/$1,107

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Human SMAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85502

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.1 kDa

Price:

20 µg/$150

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Human SMAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85503

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.8 kDa

Price:

20 µg/$150

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Human SMAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85504

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.1 kDa

Price:

20 µg/$150

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Mouse SMAD2 Protein (Recombinant His-GST) (Ser2-Ser467) - LS-G98280

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

80 kDa

Price:

100 µg/$843

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SMAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99257

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.1 kDa

Price:

100 µg/$494

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SMAD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100667

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.1 kDa

Price:

100 µg/$494

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Human SMAD2 Protein (Over-Expression Lysate His, N-Terminal) (Ser2-Ser467) - LS-G96981

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~55 kDa

Price:

100 µg/$298

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Human SMAD2 Protein (Recombinant His) - LS-G535

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human SMAD2 Protein (Recombinant 6His, N-terminus) (Ser2-Ser467) - LS-G51857

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

54.6kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627

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Mouse SMAD2 Protein (Recombinant His) (aa272-467) - LS-G14790

Source:

E. coli

Tag:

His

Molecular Weight:

23.6 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

Select

Human SMAD2 Protein (Recombinant His) (aa274-467) - LS-G14794

Source:

E. coli

Tag:

His

Molecular Weight:

23.4 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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