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Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
Gene Name: | SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) |
Synonyms: | SLX1B, GIYD1, GIY-YIG domain containing 2, GIYD2, SLX1 |
Target Sequences: | NM_024044 NP_076949.1 |
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