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Members of the SLITRK family, such as SLITRK3, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK3, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).
Gene Name: | SLIT and NTRK-like family, member 3 |
Synonyms: | SLITRK3, KIAA0848, Slit and trk like gene 3, SLIT and NTRK-like protein 3 |
Target Sequences: | NM_014926 NP_055741.2 O94933 |
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