SLIT2

slit homolog 2 (Drosophila)

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

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Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

SLIT2 (10)

Publications

No (10)

Tag

DDK,C-terminus (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (3)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human SLIT2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71137

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

169.7 kDa

Price:

20 µg/$1,107

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Human SLIT2 Protein (Recombinant His, N-Terminal) (Val1160-Cys1333) - LS-G12589

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

20.1 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human SLIT2 Protein (Recombinant His, N-Terminal) (aa1416-1528) - LS-G12590

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

14.0 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human SLIT2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88959

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

169.7 kDa

Price:

20 µg/$215

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Mouse SLIT2 Protein (Recombinant His, N-Terminal) (Cys1408-Cys1519) - LS-G24081

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

13.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Human SLIT2 Protein (Recombinant GST, N-terminus) (aa1361-1460) - LS-G61087

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SLIT2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100391

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

169.7 kDa

Price:

100 µg/$710

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Rat SLIT2 Protein (Recombinant His) (aa209-374) - LS-G12595

Source:

E. coli

Tag:

His

Molecular Weight:

20.0 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Human SLIT2 Protein (Recombinant DDK,C-terminus) - LS-G134248

Source:

HEK 293 Cells

Tag:

DDK,C-terminus

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~55 kDa

Price:

10 µg/$288

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Mouse SLIT2 Protein (Recombinant His) (aa31-197) - LS-G12591

Source:

E. coli

Tag:

His

Molecular Weight:

20.6 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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