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solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3- secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.

Gene Name: solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
Family/Subfamily: Transporter , Monovalent cation:proton antiporter-1
Synonyms: SLC9A4, Na(+)/H(+) exchanger 4, NHE-4, Sodium/hydrogen exchanger 4, NHE4
Target Sequences: NM_001011552 IPI00096898.1 Q6AI14

Filtered by: None
Over-Expression Lysate (1)
SLC9A4 / NHE4 (1)
Myc + DDK (1)
HEK 293 Cells (1)
No (1)
Showing 1-1 of 1 results

SLC9A4 / NHE4 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G121783
HEK 293 Cells
Myc + DDK
89.6 kDa
100µg  $475.00
Showing 1-1 of 1 results


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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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