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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SLC9A4 / NHE4

solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3- secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.

Gene Name: solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
Family/Subfamily: Transporter , Monovalent cation:proton antiporter-1
Synonyms: SLC9A4, Na(+)/H(+) exchanger 4, NHE-4, Sodium/hydrogen exchanger 4, NHE4
Target Sequences: NM_001011552 IPI00096898.1 Q6AI14

Filtered By: None
Type
Over-Expression Lysate (1)
Target
SLC9A4 / NHE4 (1)
Tag
Myc + DDK (1)
Source
HEK 293 Cells (1)
Showing 1-1 of 1 results

SLC9A4 / NHE4 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G121783
HEK 293 Cells
850 AA
Myc + DDK
89.6 kDa
100µg  $475.00
Showing 1-1 of 1 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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