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SLC9A3R2 / SIP1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLC9A3R2 / SIP1 is a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Gene Name: | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 |
| Family/Subfamily: | Transporter , Monovalent cation:proton antiporter-1 |
| Synonyms: | SLC9A3R2, E3KARP, NHERF-2, NHE3 regulatory factor 2, NHERF2, OCTS2, SIP1, SIP-1, TKA-1, NHE3RF2, SRY-interacting protein 1 |
| Target Sequences: | NM_004785 NP_004776.3 Q15599 |
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