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SLC9A3R1 / NHERF1 / EBP50

solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.

Gene Name: solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Family/Subfamily: Transporter , Monovalent cation:proton antiporter-1
Synonyms: SLC9A3R1, EBP50, NPHLOP2, NHERF, NHERF-1, NHERF1
Target Sequences: NM_004252 NP_004243.1 O14745

Publications (2)

1
Cell cycle dependent association of EBP50 with protein phosphatase 2A in endothelial cells. Boratk A, Gergely P, Csortos C. PloS one. 2012 7:e35595. [PubMed:22523604] [PMC:PMC3327649] Related Antibodies: LS-C161280.
2
PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system. Jagan IC, Deevi RK, Fatehullah A, Topley R, Eves J, Stevenson M, Loughrey M, Arthur K, Campbell FC. Neoplasia (New York, N.Y.). 2013 15:1218-30. (WB; Human) [PubMed:24348097] [PMC:PMC3858899] Related Antibodies: LS-B1873.

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
SLC9A3R1 / NHERF1 / EBP50 (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
SLC9A3R1 / NHERF1 / EBP50 Protein - 12.5% SDS-PAGE of human SLC9A3R1 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.3 kDa
10 µg/$479; 25 µg/$670
SLC9A3R1 / NHERF1 / EBP50 Protein - Purified recombinant protein SLC9A3R1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
38.7 kDa
20 µg/$1,107
SLC9A3R1 / NHERF1 / EBP50 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
38.7 kDa
20 µg/$150
SLC9A3R1 / NHERF1 / EBP50 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).