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SLC9A3 / NHE3

solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Gene Name: solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Family/Subfamily: Transporter , Monovalent cation:proton antiporter-1
Synonyms: SLC9A3, Na+/H+ exchanger 3, NHE3, Sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, NHE-3
Target Sequences: NM_004174 NP_004165.2 P48764

Publications (10)

1
Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Biemesderfer D, Rutherford PA, Nagy T, Pizzonia JH, Abu-Alfa AK, Aronson PS. The American journal of physiology. 1997 273:F289-99. [PubMed:9277590]
2
Membrane topology of NHE3. Epitopes within the carboxyl-terminal hydrophilic domain are exoplasmic. Biemesderfer D, DeGray B, Aronson PS. The Journal of biological chemistry. 1998 273:12391-6. [PubMed:9575193]
3
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1999 276:F711-9. [PubMed:10330053]
4
Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule. Biemesderfer D, Nagy T, DeGray B, Aronson PS. The Journal of biological chemistry. 1999 274:17518-24. [PubMed:10364184]
5
Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules. Girardi AC, Titan SM, Malnic G, Rebouas NA. Kidney international. 2000 58:1623-31. [PubMed:11012896]
6
Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis. Bagnis C, Marsolais M, Biemesderfer D, Laprade R, Breton S. American journal of physiology. Renal physiology. 2001 280:F426-36. [PubMed:11181404]
7
Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites. Kocinsky HS, Girardi AC, Biemesderfer D, Nguyen T, Mentone S, Orlowski J, Aronson PS. American journal of physiology. Renal physiology. 2005 289:F249-58. (ICC, IHC, WB, ELISA) [PubMed:15687252]
8
NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Kocinsky HS, Dynia DW, Wang T, Aronson PS. American journal of physiology. Renal physiology. 2007 293:F212-8. [PubMed:17409282]
9
NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Dynia DW, Steinmetz AG, Kocinsky HS. American journal of physiology. Renal physiology. 2010 298:F745-53. [PubMed:20015946] [PMC:PMC2838583]
10
Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Rieg T, Gerasimova M, Murray F, Masuda T, Tang T, Rose M, Drucker DJ, Vallon V. American journal of physiology. Renal physiology. 2012 303:F963-71. (WB; Mouse) [PubMed:22832924] [PMC:PMC3469689]
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SLC9A3 / NHE3 (1)
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Wheat Germ Extract (1)
SLC9A3 / NHE3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).