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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SLC9A3 / NHE3

solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Gene Name: solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Family/Subfamily: Transporter , Monovalent cation:proton antiporter-1
Synonyms: SLC9A3, Na+/H+ exchanger 3, NHE3, Sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, NHE-3
Target Sequences: NM_004174 NP_004165.2 P48764

Publications (10)

1
Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Biemesderfer D, Rutherford PA, Nagy T, Pizzonia JH, Abu-Alfa AK, Aronson PS. The American journal of physiology. 1997 273:F289-99. [PubMed:9277590]
2
Membrane topology of NHE3. Epitopes within the carboxyl-terminal hydrophilic domain are exoplasmic. Biemesderfer D, DeGray B, Aronson PS. The Journal of biological chemistry. 1998 273:12391-6. [PubMed:9575193]
3
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. The American journal of physiology. 1999 276:F711-9. [PubMed:10330053]
4
Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule. Biemesderfer D, Nagy T, DeGray B, Aronson PS. The Journal of biological chemistry. 1999 274:17518-24. [PubMed:10364184]
5
Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules. Girardi AC, Titan SM, Malnic G, Rebouas NA. Kidney international. 2000 58:1623-31. [PubMed:11012896]
6
Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis. Bagnis C, Marsolais M, Biemesderfer D, Laprade R, Breton S. American journal of physiology. Renal physiology. 2001 280:F426-36. [PubMed:11181404]
7
Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites. Kocinsky HS, Girardi AC, Biemesderfer D, Nguyen T, Mentone S, Orlowski J, Aronson PS. American journal of physiology. Renal physiology. 2005 289:F249-58. (ICC, IHC, WB, ELISA) [PubMed:15687252]
8
NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Kocinsky HS, Dynia DW, Wang T, Aronson PS. American journal of physiology. Renal physiology. 2007 293:F212-8. [PubMed:17409282]
9
NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Dynia DW, Steinmetz AG, Kocinsky HS. American journal of physiology. Renal physiology. 2010 298:F745-53. [PubMed:20015946] [PMC:PMC2838583]
10
Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Rieg T, Gerasimova M, Murray F, Masuda T, Tang T, Rose M, Drucker DJ, Vallon V. American journal of physiology. Renal physiology. 2012 303:F963-71. (WB; Mouse) [PubMed:22832924] [PMC:PMC3469689]
more

Viewing 1-25 of 48 items
SLC9A3 / NHE3 Antibody - Sodium / Hydrogen Exchanger 3 [phospho Ser552] Antibody (14D5) - Detection of NHE3 [S552] in human kidney lysate..  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 14D5] to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µl   2mg/ml   $335.00
SLC9A3 / NHE3 Antibody - Sodium / Hydrogen Exchanger 3 [phospho Ser552] Antibody (14D5) - Detection of NHE3 [S552] in human kidney lysate..  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 14D5] (IgG2a) to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum, Primate, Human
ELISA, IF, IHC, IP, WB
Biotin Conjugated
100µl   $365.00
SLC9A3 / NHE3 Antibody - Sodium / Hydrogen Exchanger 3 [phospho Ser552] Antibody (14D5) - Detection of NHE3 [S552] in human kidney lysate..  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 14D5] to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum, Human
ELISA, IF, IHC, IP, WB
DY650 Conjugated
100µl   $365.00
SLC9A3 / NHE3 Antibody - Sodium / Hydrogen Exchanger 3 [phospho Ser552] Antibody (14D5) - Detection of NHE3 [S552] in human kidney lysate..  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 14D5] to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum, Human
ELISA, IF, IHC, IP, WB
DY488 Conjugated
100µl   $365.00
SLC9A3 / NHE3 Antibody - Sodium / Hydrogen Exchanger 3 [phospho Ser552] Antibody (14D5) - Detection of NHE3 [S552] in human kidney lysate..  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 14D5] to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum, Human
ELISA, IF, IHC, IP, WB
DY550 Conjugated
100µl   $365.00
SLC9A3 / NHE3 Antibody - Western blot analysis of NHE3 in rat kidney tissues using a 1:1000 dilution of SLC9A3 / NHE3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat SLC9A3 / NHE3
Mouse, Rat
ICC, WB
Unconjugated
100µg   1mg/ml   $375.00
SLC9A3 / NHE3 Antibody - Western blot analysis of NHE3 in rat kidney tissues using a 1:1000 dilution of SLC9A3 / NHE3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat SLC9A3 / NHE3
Mouse, Rat
ICC, WB
Atto 390 Conjugated
100µg   $405.00
SLC9A3 / NHE3 Antibody - Western blot analysis of NHE3 in rat kidney tissues using a 1:1000 dilution of SLC9A3 / NHE3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat SLC9A3 / NHE3
Mouse, Rat
ICC, WB
Atto 488 Conjugated
100µg   $405.00
Select
Mouse Monoclonal [clone 10A8] (IgG2b) to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum
ICC, IF, IP, WB
Unconjugated
100µl   $335.00
Select
Mouse Monoclonal [clone 10A8] (IgG2b) to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum, Primate
ICC, IF, IP, WB
Biotin Conjugated
100µl   $365.00
Select
Mouse Monoclonal [clone 10A8] (IgG2b) to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum
ICC, IF, IP, WB
DY488 Conjugated
100µl   $365.00
Select
Mouse Monoclonal [clone 10A8] (IgG2b) to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum
ICC, IF, IP, WB
DY650 Conjugated
100µl   $365.00
Select
Mouse Monoclonal [clone 10A8] (IgG2b) to Rat SLC9A3 / NHE3
Rabbit, Mouse, Rat, Opossum
ICC, IF, IP, WB
DY550 Conjugated
100µl   $365.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IHC-P, IP, WB
Unconjugated
100µg   $620.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IP, WB
HRP Conjugated
100µl   $845.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IP, WB
Biotin Conjugated
100µl   $845.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IP, WB
FITC Conjugated
100µl   $845.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IP, WB
AP Conjugated
100µl   $845.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IP, WB
APC Conjugated
100µl   $845.00
Select
Mouse Monoclonal (IgG1) to Rabbit SLC9A3 / NHE3
Rabbit, Rat
ICC, IHC, IP, WB
PE Conjugated
100µl   $845.00
Select
Rabbit Polyclonal to Human SLC9A3 / NHE3
Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
SLC9A3 / NHE3 Antibody
Select
Rabbit Polyclonal (IgG) to Human SLC9A3 / NHE3
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Rat SLC9A3 / NHE3
Mouse, Rat
ICC, WB
Unconjugated
100µl   $575.00
Select
Rabbit Polyclonal (IgG) to Rat SLC9A3 / NHE3
Rat
ELISA, WB
Unconjugated
50µg   $665.00
Select
Rabbit Polyclonal (IgG) to Rat SLC9A3 / NHE3
Rat
ELISA, WB
Unconjugated
100µg   $755.00

Viewing 1-25 of 48 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).