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SLC7A6
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
| Gene Name: | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 |
| Family/Subfamily: | Transporter , Cationic amino acid transporter |
| Synonyms: | SLC7A6, Amino acid permease, LAT-2, LAT3, Y+LAT-2, Y+LAT2, Y+L amino acid transporter 2, KIAA0245 |
| Target Sequences: | BC028216 AAH28216.1 Q92536 |
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