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Unfortunately, the antibody (ID:188550) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



SLC7A11 / XCT

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

SLC7A11 / XCT is a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene Name: solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Family/Subfamily: Transporter , Cationic amino acid transporter
Synonyms: SLC7A11, CCBR1, Cystine/glutamate transporter, XCT
Target Sequences: NM_014331 NP_055146.1 Q9UPY5

Publications (10)

1
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sade W, Huang Y. Molecular pharmacology. 2007 72:1637-46. (WB; Human) [PubMed:17875604]
2
Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium. Langford MP, Redmond P, Chanis R, Misra RP, Redens TB. Current eye research. 2010 35:202-11. (ICC; Human) [PubMed:20373878]
3
Astrocytic redox remodeling by amyloid beta peptide. Garg SK, Vitvitsky V, Albin R, Banerjee R. Antioxidants & redox signaling. 2011 14:2385-97. (WB; Mouse) [PubMed:21235355] [PMC:PMC3096517]
4
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Zhang L, Gavin T, Barber DS, LoPachin RM. Toxicology letters. 2011 205:7-Jan. (WB; Rat) [PubMed:21540084] [PMC:PMC3149808]
5
Activated human CD4+ T cells express transporters for both cysteine and cystine. Levring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A, Odum N, Bonefeld CM, Geisler C. Scientific reports. 2012 2:266. [PubMed:22355778] [PMC:PMC3278673]
6
Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir. Ferrucci A, Nonnemacher MR, Cohen EA, Wigdahl B. Virus research. 2012 167:358-69. (ICC; Human) [PubMed:22691542] [PMC:PMC3398186]
7
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Baek S, Choi CM, Ahn SH, Lee JW, Gong G, Ryu JS, Oh SJ, Bacher-Stier C, Fels L, Koglin N, Hultsch C, Schatz CA, Dinkelborg LM, Mittra ES, Gambhir SS, Moon DH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:5427-37. (IHC; Human) [PubMed:22893629]
8
Early intraarticular injection of hyaluronic acid attenuates osteoarthritis progression in anterior cruciate ligament-transected rats. Tsai WY, Wu JL, Liu CC, Cherng CH, Tsai RY, Jean YH, Wong CS. Connective tissue research. 2013 54:49-54. (WB; Human) [PubMed:23020698]
9
The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis. Balza E, Castellani P, Delfino L, Truini M, Rubartelli A. Carcinogenesis. 2013 34:620-6. [PubMed:23161574]
10
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies. Baek S, Mueller A, Lim YS, Lee HC, Lee YJ, Gong G, Kim JS, Ryu JS, Oh SJ, Lee SJ, Bacher-Stier C, Fels L, Koglin N, Schatz CA, Dinkelborg LM, Moon DH. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 54:117-23. [PubMed:23232273]
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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Human IHC-P N-Terminus
1
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Human IHC-P N-Terminus No Primary Available
Anti-SLC7A11 / XCT Antibody (N-Terminus) IHC-plus™ LS-A3434
Immunohistochemistry Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human
IHC - Paraffin
Unconjugated
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Human IHC-P N-Terminus
1
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Human IHC-P N-Terminus No Primary Available
Anti-SLC7A11 / XCT Antibody (N-Terminus) IHC-plus™ LS-A3053
Immunohistochemistry Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human
IHC - Paraffin
Unconjugated
SLC7A11 / XCT Goat Polyclonal Unconjugated Human, Monkey IHC-P, WB, ELISA aa215-229
1
SLC7A11 / XCT Goat Polyclonal Unconjugated Human, Monkey IHC-P, WB, ELISA aa215-229 No Primary Available
Anti-SLC7A11 / XCT Antibody (aa215-229) IHC-plus™ LS-B4345
Immunohistochemistry Image
Immunohistochemistry Image
Goat Polyclonal to Human SLC7A11 / XCT
Human, Monkey
IHC - Paraffin, Western blot, ELISA
Unconjugated
SLC7A11 / XCT Rabbit Polyclonal Biotin Conjugated,DY488 Conjugated,DY550 Conjugated,DY650 Conjugated Human WB, Flo,WB, Flo,WB, Flo,WB, Flo N-Terminus
4
SLC7A11 / XCT Rabbit Polyclonal Biotin Conjugated Human WB, Flo N-Terminus No Primary
Anti-SLC7A11 / XCT Antibody (N-Terminus, Biotin) LS-C142123
Flow Cytometry Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Western blot, Flow Cytometry
Biotin Conjugated
SLC7A11 / XCT Rabbit Polyclonal DY488 Conjugated Human WB, Flo N-Terminus No Primary
Anti-SLC7A11 / XCT Antibody (N-Terminus, DY488) LS-C142125
Flow Cytometry Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Western blot, Flow Cytometry
DY488 Conjugated
SLC7A11 / XCT Rabbit Polyclonal DY550 Conjugated Human WB, Flo N-Terminus No Primary
Anti-SLC7A11 / XCT Antibody (N-Terminus, DY550) LS-C142127
Flow Cytometry Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Western blot, Flow Cytometry
DY550 Conjugated
SLC7A11 / XCT Rabbit Polyclonal DY650 Conjugated Human WB, Flo N-Terminus No Primary
Anti-SLC7A11 / XCT Antibody (N-Terminus, DY650) LS-C142124
Flow Cytometry Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Western blot, Flow Cytometry
DY650 Conjugated
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Mouse, Human WB N-Terminus
1
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Mouse, Human WB N-Terminus No Primary
Anti-SLC7A11 / XCT Antibody (N-Terminus) LS-C89187
Rabbit Polyclonal to Mouse SLC7A11 / XCT
Mouse, Human
Western blot
Unconjugated
SLC7A11 / XCT Rabbit Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human, Monkey, Mouse, Rat, Pig WB,WB,WB,WB aa215-264
4
SLC7A11 / XCT Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Pig WB aa215-264 No Primary
Anti-SLC7A11 / XCT Antibody (aa215-264) LS-C110838
Western blot Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human, Monkey, Mouse, Rat, Pig
Western blot
Unconjugated
SLC7A11 / XCT Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Pig WB aa215-264 No Primary
Anti-SLC7A11 / XCT Antibody (aa215-264, HRP) LS-C445840
Western blot Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Pig
Western blot
HRP Conjugated
SLC7A11 / XCT Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Pig WB aa215-264 No Primary
Anti-SLC7A11 / XCT Antibody (aa215-264, Biotin) LS-C445839
Western blot Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Pig
Western blot
Biotin Conjugated
SLC7A11 / XCT Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Pig WB aa215-264 No Primary
Anti-SLC7A11 / XCT Antibody (aa215-264, FITC) LS-C445841
Western blot Image
Rabbit Polyclonal to Human SLC7A11 / XCT
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Pig
Western blot
FITC Conjugated
Target Corresponding Antibodies
SLC7A11 / XCT
1
SLC7A11 / XCT Antibody Blocking Peptide - LS-E26198
LS-E26198
SLC7A11 / XCT
LS-B4345
SLC7A11 / XCT
1
SLC7A11 / XCT Antibody Blocking Peptide - LS-E28678
LS-E28678
SLC7A11 / XCT
LS-A3053
SLC7A11 / XCT
1
SLC7A11 / XCT Antibody Blocking Peptide - LS-E28749
LS-E28749
SLC7A11 / XCT
LS-A3434
Type Target Reactivity Sample Type
Sandwich SLC7A11 / XCT Human Cell Culture Supernatants, Serum, Tissue Homogenates, Plasma
1
Human SLC7A11 / XCT ELISA Kit (Sandwich ELISA) - LS-F12984
 Image
 Image
Quantitative Sandwich ELISA
96-Well Strip Plate
Human
0.156-10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum, Tissue Homogenates, Plasma
Sandwich SLC7A11 / XCT Rat Cell Lysates, Tissue Homogenates
1
Rat SLC7A11 / XCT ELISA Kit (Sandwich ELISA) - LS-F9856
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Rat
1.56-100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
Sandwich (Custom) SLC7A11 / XCT Mouse
1
Mouse SLC7A11 / XCT ELISA Kit (Sandwich ELISA) (Custom) - LS-F15997
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant SLC7A11 / XCT GST Human Wheat Purified
1
Human SLC7A11 / XCT Recombinant (GST) Protein - LS-G32943
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Wheat Wheat Germ Extract
501 AA
GST
Purified
81.8 kDa

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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