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Unfortunately, the antibody (ID:188550) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



SLC7A11 / XCT

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

SLC7A11 / XCT is a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene Name: solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Family/Subfamily: Transporter , Cationic amino acid transporter
Synonyms: SLC7A11, CCBR1, Cystine/glutamate transporter, XCT
Target Sequences: NM_014331 NP_055146.1 Q9UPY5

Publications (10)

1
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sade W, Huang Y. Molecular pharmacology. 2007 72:1637-46. (WB; Human) [PubMed:17875604]
2
Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium. Langford MP, Redmond P, Chanis R, Misra RP, Redens TB. Current eye research. 2010 35:202-11. (ICC; Human) [PubMed:20373878]
3
Astrocytic redox remodeling by amyloid beta peptide. Garg SK, Vitvitsky V, Albin R, Banerjee R. Antioxidants & redox signaling. 2011 14:2385-97. (WB; Mouse) [PubMed:21235355] [PMC:PMC3096517]
4
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Zhang L, Gavin T, Barber DS, LoPachin RM. Toxicology letters. 2011 205:7-Jan. (WB; Rat) [PubMed:21540084] [PMC:PMC3149808]
5
Activated human CD4+ T cells express transporters for both cysteine and cystine. Levring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A, Odum N, Bonefeld CM, Geisler C. Scientific reports. 2012 2:266. [PubMed:22355778] [PMC:PMC3278673]
6
Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir. Ferrucci A, Nonnemacher MR, Cohen EA, Wigdahl B. Virus research. 2012 167:358-69. (ICC; Human) [PubMed:22691542] [PMC:PMC3398186]
7
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Baek S, Choi CM, Ahn SH, Lee JW, Gong G, Ryu JS, Oh SJ, Bacher-Stier C, Fels L, Koglin N, Hultsch C, Schatz CA, Dinkelborg LM, Mittra ES, Gambhir SS, Moon DH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:5427-37. (IHC; Human) [PubMed:22893629]
8
Early intraarticular injection of hyaluronic acid attenuates osteoarthritis progression in anterior cruciate ligament-transected rats. Tsai WY, Wu JL, Liu CC, Cherng CH, Tsai RY, Jean YH, Wong CS. Connective tissue research. 2013 54:49-54. (WB; Human) [PubMed:23020698]
9
The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis. Balza E, Castellani P, Delfino L, Truini M, Rubartelli A. Carcinogenesis. 2013 34:620-6. [PubMed:23161574]
10
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies. Baek S, Mueller A, Lim YS, Lee HC, Lee YJ, Gong G, Kim JS, Ryu JS, Oh SJ, Lee SJ, Bacher-Stier C, Fels L, Koglin N, Schatz CA, Dinkelborg LM, Moon DH. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 54:117-23. [PubMed:23232273]
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Filtered By: None
Target
slc7a11-xct (12)
Reactivity
Human (12)
Mouse (5)
Rat (4)
Chimpanzee (3)
Gibbon (3)
Monkey (5)
Orangutan (3)
Pig (4)
Application
IHC-P (3)
WB (10)
Flo (4)
ELISA (1)
Host
rabbit (11)
goat (1)
Clonality
polyclonal pc (12)
Format
Biotin Conjugated (2)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (5)
Epitope
N-Terminus (7)
aa215-264 (4)
aa215-229 (1)
Publications
No (12)
Showing 1-12 out of 12 results
Anti-SLC7A11 / XCT Antibody (N-Terminus) IHC-plus™ LS-A3053

Rabbit Polyclonal to Human SLC7A11 / XCT
Human
IHC-P
Unconjugated
Anti-SLC7A11 / XCT Antibody (aa215-229) IHC-plus™ LS-B4345

Goat Polyclonal to Human SLC7A11 / XCT
Human, Monkey
ELISA IHC-P WB
Unconjugated
Anti-SLC7A11 / XCT Antibody (N-Terminus) IHC-plus™ LS-A3434

Rabbit Polyclonal to Human SLC7A11 / XCT
Human
IHC-P
Unconjugated
Anti-SLC7A11 / XCT Antibody (aa215-264) LS-C110838

Rabbit Polyclonal to Human SLC7A11 / XCT
Mouse, Rat, Pig, Human, Monkey
WB
Unconjugated
Anti-SLC7A11 / XCT Antibody (aa215-264, HRP) LS-C445840

Rabbit Polyclonal to Human SLC7A11 / XCT
Mouse, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
Anti-SLC7A11 / XCT Antibody (aa215-264, Biotin) LS-C445839

Rabbit Polyclonal to Human SLC7A11 / XCT
Mouse, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
Anti-SLC7A11 / XCT Antibody (aa215-264, FITC) LS-C445841

Rabbit Polyclonal to Human SLC7A11 / XCT
Mouse, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
Anti-SLC7A11 / XCT Antibody (N-Terminus, Biotin) LS-C142123

Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Flo WB
Biotin Conjugated
Anti-SLC7A11 / XCT Antibody (N-Terminus, DY650) LS-C142124

Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Flo WB
DY650 Conjugated
Anti-SLC7A11 / XCT Antibody (N-Terminus, DY488) LS-C142125

Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Flo WB
DY488 Conjugated
Anti-SLC7A11 / XCT Antibody (N-Terminus, DY550) LS-C142127

Rabbit Polyclonal to Human SLC7A11 / XCT
Human
Flo WB
DY550 Conjugated
Anti-SLC7A11 / XCT Antibody (N-Terminus) LS-C89187

Rabbit Polyclonal to Mouse SLC7A11 / XCT
Mouse, Human
WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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