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SLC6A2 / NET
solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A2 / NET is a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
| Gene Name: | solute carrier family 6 (neurotransmitter transporter), member 2 |
| Family/Subfamily: | Transporter , Neurotransmitter:sodium symporter |
| Synonyms: | SLC6A2, NET, Neurotransmitter transporter, Noradrenaline transporter, Norepinephrine transporter |
| Target Sequences: | NM_001043 NP_001034.1 P23975 |
Publications (1)
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