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SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
Acts as an electroneutral and low-affinity sodium (Na+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate.
| Gene Name: | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 |
| Family/Subfamily: | Transporter , Solute:sodium symporter |
| Synonyms: | SLC5A12, SMCT2 |
| Target Sequences: | AX191522 CAC51158.1 Q1EHB4 |
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